Photobiomodulation in the management of oral mucositis for adult head and neck cancer patients receiving irradiation: the LiTEFORM RCT

Nugent, Michael; Bryant, Valerie; Butcher, Chrissie; Fisher, Holly; Gill, Sean; Goranova, Rebecca; Hiu, Shaun; Lindley, Lyndsay; O’Hara, James; Oluboyede, Yemi; Patterson, Joanne; Rapley, Tim; Robinson, Tomos; Rousseau, Nikki; Ryan, Vicky; Shanmugasundaram, Ramkumar; Sharp, Linda; Smith Whelan, Ruby; Stocken, Deborah D; Ternent, Laura; Wilson, Janet; Walker, Jenn

doi:10.3310/UWNB3375

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This trial only recruited 21% of its target due to lack of capacity, however, its novel qualitative findings and sham design can inform photobiomodulation researchers and service providers.

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Michael Nugent ^1,^*, Valerie Bryant ², Chrissie Butcher ³, Holly Fisher ⁴, Sean Gill ³, Rebecca Goranova ⁵, Shaun Hiu ⁴, Lyndsay Lindley ⁶, James O’Hara ⁷, Yemi Oluboyede ⁴, Joanne Patterson ⁸, Tim Rapley ⁹, Tomos Robinson ⁴, Nikki Rousseau ^4,¹⁰, Vicky Ryan ⁴, Ramkumar Shanmugasundaram ¹¹, Linda Sharp ⁴, Ruby Smith Whelan ³, Deborah D Stocken ¹⁰, Laura Ternent ⁴, Janet Wilson ⁴, Jenn Walker ³

¹ Department of Oral and Maxillofacial Surgery, City Hospitals Sunderland NHS Foundation Trust, Sunderland, UK
² Change Head and Neck Cancer Research Patient Involvement Group, Sunderland, UK
³ Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK
⁴ Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK
⁵ Plymouth Oncology Centre, University Hospitals Plymouth NHS Trust, Plymouth, UK
⁶ Social Policy Research Unit, University of York, York, UK
⁷ Ear, Nose and Throat Department, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
⁸ School of Health Sciences, University of Liverpool, Liverpool, UK
⁹ Department of Social Work, Education and Community Wellbeing, Northumbria University, Newcastle upon Tyne, UK
¹⁰ Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK
¹¹ Clinical Oncology, University Hospital Southampton NHS Foundation Trust, Southampton, UK
^* Corresponding author Email: Michaelnugent@nhs.net

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