Probiotics to reduce antibiotic administration in care home residents aged 65 years and older: the PRINCESS RCT

Butler, Christopher C; Owen-Jones, Eleri; Lau, Mandy; Gillespie, David; Lown, Mark; Calder, Philip C; Stanton, Helen; Wootton, Mandy; Castro Herrera, Vivian; Bayer, Antony; Davies, Jane; Edwards, Alison; Davoudianfar, Mina; Rutter, Heather; Hood, Kerenza; Moore, Michael; Little, Paul; Shepherd, Victoria; Lowe, Rachel; Miles, Elizabeth A; Townson, Julia; Hobbs, FD Richard; Francis, Nick A

doi:10.3310/eme08070

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Daily consumption of two common probiotic strains did not reduce cumulative systemic antibiotic administration days for all-cause acute infections in care home residents.

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Christopher C Butler ^1,^*, Eleri Owen-Jones ², Mandy Lau ², David Gillespie ², Mark Lown ³, Philip C Calder ⁴, Helen Stanton ², Mandy Wootton ⁵, Vivian Castro Herrera ⁴, Antony Bayer ⁶, Jane Davies ², Alison Edwards ², Mina Davoudianfar ¹, Heather Rutter ¹, Kerenza Hood ², Michael Moore ³, Paul Little ³, Victoria Shepherd ², Rachel Lowe ², Elizabeth A Miles ⁴, Julia Townson ², FD Richard Hobbs ¹, Nick A Francis ³

¹ Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK
² Centre for Trials Research, Cardiff University, Cardiff, UK
³ Primary Care, Population Sciences and Medical Education, University of Southampton, Southampton, UK
⁴ Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK
⁵ Specialist Antimicrobial Chemotherapy Unit, Public Health Wales Microbiology Cardiff, University Hospital of Wales, Cardiff, UK
⁶ Division of Population Medicine, School of Medicine, Cardiff University, Cardiff, UK
^* Corresponding author Email: Christopher.butler@phc.ox.ac.uk

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