A duodenal sleeve bypass device added to intensive medical therapy for obesity with type 2 diabetes: a RCT

Ruban, Aruchuna; Glaysher, Michael A; Miras, Alexander D; Goldstone, Anthony P; Prechtl, Christina G; Johnson, Nicholas; Li, Jia; Aldhwayan, Madhawi; Aldubaikhi, Ghadah; Glover, Ben; Lord, Joanne; Onyimadu, Olu; Falaschetti, Emmanuela; Klimowska-Nassar, Natalia; Ashrafian, Hutan; Byrne, James; Teare, Julian P

doi:10.3310/eme07060

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This trial found that the endoluminal duodenal jejunal bypass liner was not superior to intensive medical therapy for glycaemic control and it was associated with more adverse events.

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Aruchuna Ruban ^1,^*, Michael A Glaysher ², Alexander D Miras ³, Anthony P Goldstone ⁴, Christina G Prechtl ⁵, Nicholas Johnson ⁵, Jia Li ¹, Madhawi Aldhwayan ³, Ghadah Aldubaikhi ⁴, Ben Glover ¹, Joanne Lord ⁶, Olu Onyimadu ⁶, Emmanuela Falaschetti ⁵, Natalia Klimowska-Nassar ⁵, Hutan Ashrafian ¹, James Byrne ⁷, Julian P Teare ¹

¹ Department of Surgery and Cancer, St Mary’s Hospital, Imperial College London, London, UK
² National Institute for Health Research Southampton Biomedical Research Centre, Southampton Centre for Biomedical Research, Southampton General Hospital, Southampton, UK
³ Section of Investigative Medicine, Division of Diabetes, Endocrinology and Metabolic Medicine, Hammersmith Hospital, Imperial College London, London, UK
⁴ PsychoNeuroEndocrinology Research Group, Neuropsychopharmacology Unit, Centre for Psychiatry and Computational, Cognitive and Clinical Neuroimaging Laboratory, Division of Brain Sciences, Imperial College London, London, UK
⁵ Department of Public Health, Imperial Clinical Trials Unit, Imperial College London, London, UK
⁶ University of Southampton, Southampton Health Technology Assessments Centre, University of Southampton Science Park, Southampton, UK
⁷ Division of Surgery, University Hospital Southampton NHS Foundation Trust, Southampton, UK
^* Corresponding author Email: a.mohanaruban@imperial.ac.uk

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