Minocycline 200 mg or 400 mg versus placebo for mild Alzheimer's disease: the MADE Phase II, three-arm RCT

Howard, Robert; Zubko, Olga; Gray, Richard; Bradley, Rosie; Harper, Emma; Kelly, Linda; Pank, Lynn; O’Brien, John; Fox, Chris; Tabet, Naji; Livingston, Gill; Bentham, Peter; McShane, Rupert; Burns, Alistair; Ritchie, Craig; Reeves, Suzanne; Lovestone, Simon; Ballard, Clive; Noble, Wendy; Wilcock, Gordon; Nilforooshan, Ramin

doi:10.3310/eme07020

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Minocycline did not delay the progress of cognitive or functional impairment in people with mild Alzheimer's disease over 2 years and minocycline 400 mg was poorly tolerated.

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Robert Howard ^1,^*, Olga Zubko ², Richard Gray ³, Rosie Bradley ⁴, Emma Harper ⁴, Linda Kelly ⁴, Lynn Pank ⁴, John O’Brien ⁵, Chris Fox ⁶, Naji Tabet ⁷, Gill Livingston ¹, Peter Bentham ⁸, Rupert McShane ⁹, Alistair Burns ¹⁰, Craig Ritchie ¹¹, Suzanne Reeves ¹, Simon Lovestone ⁹, Clive Ballard ¹², Wendy Noble ¹³, Gordon Wilcock ¹⁴, Ramin Nilforooshan ¹⁵

¹ Division of Psychiatry, University College London, London, UK
² Department of Old Age Psychiatry, King’s College London, London, UK
³ Nuffield Department of Population Health, University of Oxford, Oxford, UK
⁴ Medical Research Council Population Health Research Unit, University of Oxford, Oxford, UK
⁵ Department of Psychiatry, University of Cambridge, Cambridge, UK
⁶ Norwich Medical School, University of East Anglia, Norwich, UK
⁷ Department of Old Age Psychiatry, University of Sussex, Brighton, UK
⁸ The Barberry Centre, Birmingham and Solihull Mental Health NHS Foundation Trust, Birmingham, UK
⁹ Department of Psychiatry, University of Oxford, Oxford, UK
¹⁰ Department of Old Age Psychiatry, University of Manchester, Manchester, UK
¹¹ Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK
¹² Medical School, University of Exeter, Exeter, UK
¹³ Department of Basic and Clinical Neuroscience, King’s College London, London, UK
¹⁴ Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
¹⁵ Abraham Cowley Unit, Surrey and Borders Partnership NHS Foundation Trust, Redhill, UK
^* Corresponding author Email: robert.howard@ucl.ac.uk

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