Simvastatin to reduce pulmonary dysfunction in patients with acute respiratory distress syndrome: the HARP-2 RCT

McAuley, Daniel F; Laffey, John G; O’Kane, Cecilia M; Perkins, Gavin D; Mullan, Brian; Trinder, Thomas J; Johnston, Paul; Hopkins, Phillip A; Johnston, Andrew J; Murphy, Lynn; McNally, Christine; Agus, Ashley M; McDowell, Clíona; Jackson, Colette

doi:10.3310/eme05010

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This study showed that simvastatin did not increase the number of ventilator-free days or improve mortality in patients with acute respiratory distress syndrome.

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Daniel F McAuley ^1,^2,^3,^*, John G Laffey ⁴, Cecilia M O’Kane ¹, Gavin D Perkins ^5,⁶, Brian Mullan ², Thomas J Trinder ⁷, Paul Johnston ⁸, Phillip A Hopkins ⁹, Andrew J Johnston ¹⁰, Lynn Murphy ³, Christine McNally ³, Ashley M Agus ³, Clíona McDowell ³, Colette Jackson ³

¹ Wellcome–Wolfson Institute for Experimental Medicine, Queen’s University Belfast, Belfast, UK
² Regional Intensive Care Unit, Royal Victoria Hospital, Belfast, UK
³ Northern Ireland Clinical Trials Unit, Royal Hospitals, Belfast, UK
⁴ Department of Anaesthesia, Clinical Sciences Institute, National University of Ireland, Galway, Ireland
⁵ Warwick Medical School Clinical Trials Unit, University of Warwick, Coventry, UK
⁶ Heart of England NHS Foundation Trust, Coventry, UK
⁷ Intensive Care Unit, The Ulster Hospital, Belfast, UK
⁸ Intensive Care Unit, Antrim Hospital, Antrim, UK
⁹ King’s Critical Care Unit, King’s College Hospital, London, UK
¹⁰ Intensive Care Unit, Addenbrooke’s Hospital, Cambridge, UK
^* Corresponding author Email: d.f.mcauley@qub.ac.uk

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