A randomised placebo-controlled Phase III multicentre trial: low-dose intravenous immunoglobulin treatment for long-standing complex regional pain syndrome (LIPS trial)

Goebel, Andreas; Bisla, Jatinder; Carganillo, Roy; Cole, Claire; Frank, Bernhard; Gupta, Rima; James, Mairi; Kelly, Joanna; McCabe, Candy; Milligan, Holly; Murphy, Caroline; Padfield, Nick; Phillips, Ceri; Poole, Helen; Saunders, Mark; Serpell, Mick; Shenker, Nick; Shoukrey, Karim; Wyatt, Lynne; Ambler, Gareth

doi:10.3310/eme04050

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Low-dose intravenous immunoglobulin was not effective in relieving pain in longstanding complex regional pain syndrome.

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Andreas Goebel ^1,^*, Jatinder Bisla ², Roy Carganillo ³, Claire Cole ¹, Bernhard Frank ⁴, Rima Gupta ⁵, Mairi James ⁶, Joanna Kelly ², Candy McCabe ^7,⁸, Holly Milligan ¹, Caroline Murphy ², Nick Padfield ³, Ceri Phillips ⁹, Helen Poole ¹⁰, Mark Saunders ¹¹, Mick Serpell ⁶, Nick Shenker ¹², Karim Shoukrey ¹³, Lynne Wyatt ⁴, Gareth Ambler ¹⁴

¹ Pain Research Institute, Clinical Sciences Centre, Liverpool, UK
² King’s Clinical Trials Unit, Institute of Psychiatry, Psychology and Neuroscience, London, UK
³ Pain Management and Neuromodulation Centre, Guy’s and St Thomas’ Hospital, London, UK
⁴ The Walton Centre NHS Foundation Trust, Liverpool, UK
⁵ Modepharma Ltd, Beckenham, UK
⁶ University Department of Anaesthesia, Queen Elizabeth University Hospital, Glasgow Clinical Research Facility, Glasgow, UK
⁷ Royal National Hospital for Rheumatic Diseases, Bath, UK
⁸ University of the West of England, Bristol, UK
⁹ College of Human and Health Sciences, Swansea University, Swansea, UK
¹⁰ Faculty of Science, Liverpool John Moores University, Liverpool, UK
¹¹ Norfolk and Norwich University NHS Trust, Norwich, UK
¹² Department of Rheumatology, Cambridge University Hospitals, Cambridge, UK
¹³ University Hospital of Leicester NHS Trust, Leicester General Hospital, Leicester, UK
¹⁴ Statistical Science, University College London, London, UK
^* Corresponding author Email: andreasgoebel@rocketmail.com/andreas.goebel@liv.ac.uk

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