The interleukin 1 receptor antagonist anakinra to reduce disease severity of palmoplantar pustulosis in adults: APRICOT RCT and PLUM mechanistic study

Cro, Suzie; Cornelius, Victoria; Capon, Francesca; Barker, Jonathan; Burden, David; Griffiths, Christopher; Lachmann, Helen Jane; McAteer, Helen; Patel, Prakash; Pink, Andrew; Reynolds, Nick; Warren, Richard; Smith, Catherine

doi:10.3310/MXPK2427

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Daily injections of anakinra did not show change in disease activity compared with placebo when assessed by the Palmoplantar Pustulosis Area and Severity Index at 8 weeks.

Suzie Cro
[Image - ORCID logo], Victoria Cornelius
[Image - ORCID logo], Francesca Capon
[Image - ORCID logo], Jonathan Barker
[Image - ORCID logo], David Burden
[Image - ORCID logo], Christopher Griffiths
[Image - ORCID logo], Helen Jane Lachmann
[Image - ORCID logo], Helen McAteer
[Image - ORCID logo], Prakash Patel
[Image - ORCID logo], Andrew Pink
[Image - ORCID logo], Nick Reynolds
[Image - ORCID logo], Richard Warren
[Image - ORCID logo] & Catherine Smith
[Image - ORCID logo].

Detailed Author information
Detailed Author information

Suzie Cro ¹, Victoria Cornelius ¹, Francesca Capon ², Jonathan Barker ³, David Burden ⁴, Christopher Griffiths ^5,⁶, Helen Jane Lachmann ⁷, Helen McAteer ⁸, Prakash Patel ⁹, Andrew Pink ⁹, Nick Reynolds ^10,^11,¹², Richard Warren ^5,^6,¹³, Catherine Smith ^9,^*

¹ Imperial Clinical Trials Unit, Imperial College London, London, UK
² Department of Medical & Molecular Genetics, King’s College London, London, UK
³ St John’s Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King’s College London, London, UK
⁴ Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, UK
⁵ Manchester Centre for Dermatology Research, University of Manchester, Manchester, UK
⁶ Salford Royal NHS Foundation Trust, Manchester, UK
⁷ The National Amyloidosis Centre, University College London, London, UK
⁸ The Psoriasis Association, Northampton, UK
⁹ St John’s Institute of Dermatology, Guy’s and St Thomas’ NHS Foundation Trust, London, UK
¹⁰ Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
¹¹ Department of Dermatology, Royal Victoria Infirmary, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
¹² National Institute for Health Research Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust and Newcastle University, Newcastle upon Tyne, UK
¹³ Manchester National Institute for Health Research Biomedical Research Centre, Manchester, UK
^* Corresponding author Email: catherine.smith@kcl.ac.uk

Funding: {{metadata.Funding}}

{{metadata.Journal}} Volume: {{metadata.Volume}}, Issue: {{metadata.Issue}}, Published in {{metadata.PublicationDate | date:'MMMM yyyy'}}

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Citation: {{author}}{{ (($index < metadata.AuthorsArray.length-1) && ($index <=6)) ? ', ' : '' }}{{(metadata.AuthorsArray.length <= 6) ? '.' : '' }} {{(metadata.AuthorsArray.length > 6) ? 'et al.' : ''}} . {{metadata.JournalShortName}} {{metadata.PublicationDate | date:'yyyy'}};{{metadata.Volume}}({{metadata.Issue}})

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