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Extended Research Article
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Adaptive stratified medicine studies are feasible in common cancers but this increases complexity and reduces the proportion of patients eligible for randomisation.

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Louise C Brown
[Image - ORCID logo], David Fisher
[Image - ORCID logo], Richard Adams
[Image - ORCID logo], Jenny Seligmann
[Image - ORCID logo], Matthew Seymour
[Image - ORCID logo], Richard Kaplan
[Image - ORCID logo], Susan D Richman
[Image - ORCID logo], Philip Quirke
[Image - ORCID logo], Rachel Butler, Helen Roberts
[Image - ORCID logo], Janet Graham
[Image - ORCID logo], Richard H Wilson
[Image - ORCID logo] & Timothy S Maughan
[Image - ORCID logo].


Louise C Brown 1, David Fisher 1, Richard Adams 2,3, Jenny Seligmann 4, Matthew Seymour 4, Richard Kaplan 1, Susan D Richman 4, Philip Quirke 4, Rachel Butler 5, Helen Roberts 2,3, Janet Graham 6,7, Richard H Wilson 6,7, Timothy S Maughan 8,*

1 Medical Research Council Clinical Trials Unit, University College London, London, UK
2 Centre for Trials Research, Cardiff University, Cardiff, UK
3 Oncology Department, Velindre Cancer Centre, Velindre University NHS Trust, Cardiff, UK
4 Leeds Institute of Medical Research, University of Leeds, Leeds, UK
5 Bristol Genetics Laboratory, Bristol, UK
6 Beatson West of Scotland Cancer Centre, Glasgow, UK
7 Institute of Cancer Sciences, University of Glasgow, Glasgow, UK
8 Department of Oncology, University of Oxford, Oxford, UK
* Corresponding author Email: tim.maughan@oncology.ox.ac.uk


Funding: {{metadata.Funding}}

{{metadata.Journal}} Volume: {{metadata.Volume}}, Issue: {{metadata.Issue}}, Published in {{metadata.PublicationDate | date:'MMMM yyyy'}}

https://doi.org/{{metadata.DOI}}

Citation: {{author}}{{ (($index < metadata.AuthorsArray.length-1) && ($index <=6)) ? ', ' : '' }}{{(metadata.AuthorsArray.length <= 6) ? '.' : '' }} {{(metadata.AuthorsArray.length > 6) ? 'et al.' : ''}} . {{metadata.JournalShortName}} {{metadata.PublicationDate | date:'yyyy'}};{{metadata.Volume}}({{metadata.Issue}})

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