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This trial did not show that tocilizumab was more effective than rituximab in patients with a B-cell-poor pathotype in the primary analysis; however, superiority was shown in most supplementary and secondary analyses using a molecular classification.
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Frances Humby
[Image - ORCID logo], Patrick Durez
[Image - ORCID logo], Maya H Buch
[Image - ORCID logo], Myles J Lewis
[Image - ORCID logo], Michele Bombardieri
[Image - ORCID logo], Christopher John
[Image - ORCID logo], Hasan Rizvi
[Image - ORCID logo], Louise Warren
[Image - ORCID logo], Joanna Peel
[Image - ORCID logo], Liliane Fossati-Jimack
[Image - ORCID logo], Rebecca E Hands
[Image - ORCID logo], Giovanni Giorli
[Image - ORCID logo], Felice Rivellese
[Image - ORCID logo], Juan D Cañete
[Image - ORCID logo], Peter C Taylor
[Image - ORCID logo], Peter Sasieni
[Image - ORCID logo], João E Fonseca
[Image - ORCID logo], Ernest Choy
[Image - ORCID logo] & Costantino Pitzalis
[Image - ORCID logo].
Frances Humby 1, Patrick Durez 2, Maya H Buch 3, Myles J Lewis 1, Michele Bombardieri 1, Christopher John 1, Hasan Rizvi 4, Louise Warren 1, Joanna Peel 1, Liliane Fossati-Jimack 1, Rebecca E Hands 1, Giovanni Giorli 1, Felice Rivellese 1, Juan D Cañete 5, Peter C Taylor 6, Peter Sasieni 7, João E Fonseca 8, Ernest Choy 9, Costantino Pitzalis 1,*
1 Centre for Experimental Medicine and Rheumatology, Queen Mary University of London, London, UK
2 Institute of Experimental and Clinical Research, Université Catholique de Louvain, Louvain, Belgium
3 Clinical Trials Research Unit, University of Leeds, Leeds, UK
4 Blizard Institute, Barts Health NHS Trust, London, UK
5 Arthritis Unit, L’Institut d’Investigacions Biomèdiques, Barcelona, Spain
6 Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK
7 King’s Clinical Trial Unit, King’s College London, London, UK
8 Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal
9 Section of Rheumatology, Cardiff University School of Medicine, Cardiff University, Cardiff, UK
* Corresponding author Email: c.pitzalis@qmul.ac.uk
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