Prognostic biomarkers to identify patients likely to develop severe Crohn's disease: a systematic review

Halligan, Steve; Boone, Darren; Archer, Lucinda; Ahmad, Tariq; Bloom, Stuart; Rodriguez-Justo, Manuel; Taylor, Stuart A; Mallett, Sue

doi:10.3310/hta25450

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This review found limited prognostic evidence for most individual biomarkers but identified eight with potential predictor capability for severe Crohn's disease.

Steve Halligan
[Image - ORCID logo], Darren Boone
[Image - ORCID logo], Lucinda Archer
[Image - ORCID logo], Tariq Ahmad
[Image - ORCID logo], Stuart Bloom
[Image - ORCID logo], Manuel Rodriguez-Justo
[Image - ORCID logo], Stuart A Taylor
[Image - ORCID logo] & Sue Mallett
[Image - ORCID logo].

Detailed Author information
Detailed Author information

Steve Halligan ^1,^*, Darren Boone ¹, Lucinda Archer ², Tariq Ahmad ³, Stuart Bloom ⁴, Manuel Rodriguez-Justo ⁵, Stuart A Taylor ¹, Sue Mallett ¹

¹ Centre for Medical Imaging, University College London, London, UK
² Centre for Prognosis Research, School of Primary, Community and Social Care, Keele University, Keele, UK
³ Department of Gastroenterology, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK
⁴ Department of Gastroenterology, University College Hospital, London, UK
⁵ Department of Histopathology, University College Hospital, London, UK
^* Corresponding author Email: s.halligan@ucl.ac.uk

Declared competing interests of authors: Sue Mallett reports grants from the University of Birmingham during the conduct of the study and a National Institute for Health Research (NIHR)-funded grant, METRIC EF (NIHR Award ID 15/59/17; https://fundingawards.nihr.ac.uk/award/15/59/17), outside the submitted work. Sue Mallett was also funded by the NIHR Birmingham Biomedical Research Centre. Tariq Ahmad reports grants and personal fees from AbbVie, Inc. (North Chicago, IL, USA), Celltrion (Incheon, Republic of Korea) and Celgene Corporation (Summit, NJ, USA), and personal fees from Takeda Pharmaceutical Company (Tokyo, Japan) and Pfizer, Inc. (New York, NY, USA) outside the submitted work. Stuart A Taylor reports personal fees from Alimentiv Inc. (London, ON, Canada) outside the submitted work. Steve Halligan reports grants from the NIHR Health Technology Assessment programme outside the submitted work during the conduct of the study. Stuart A Taylor, Manuel Rodriguez-Justo and Steve Halligan were also supported by the NIHR University College London Hospitals Biomedical Research Centre. Lucinda Archer was funded by the UK NIHR Research Methods Fellowship.

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