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Specific reported study design characteristics are associated with exaggeration of beneficial intervention effect estimates and increases in between-trial heterogeneity, with these effects being greatest for subjectively assessed outcomes.
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J Savović, HE Jones, DG Altman, RJ Harris, P Jűni, J Pildal, B Als-Nielsen, EM Balk, C Gluud, LL Gluud, JPA Ioannidis, KF Schulz, R Beynon, N Welton, L Wood, D Moher, JJ Deeks & JAC Sterne.
J Savović 1, HE Jones 1, DG Altman 2, RJ Harris 3, P Jűni 4, J Pildal 5, B Als-Nielsen 6, EM Balk 7, C Gluud 8, LL Gluud 9, JPA Ioannidis 10, KF Schulz 11, R Beynon 1, N Welton 1, L Wood 12, D Moher 13, JJ Deeks 14, JAC Sterne 1,*
1 School of Social and Community Medicine, University of Bristol, Bristol, UK
2 Centre for Statistics in Medicine, University of Oxford, Wolfson College, Oxford, UK
3 Centre for Infections, Health Protection Agency, Colindale, UK
4 Division of Clinical Epidemiology and Biostatistics, Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland; CTU Bern, Bern University Hospital, Bern, Switzerland
5 The Nordic Cochrane Centre, Rigshospitalet, Copenhagen, Denmark
6 Copenhagen Trial Unit, Centre for Clinical Intervention Research and Department of Paediatrics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
7 Center for Clinical Evidence Synthesis, Tufts Clinical and Translational Science Institute, Tufts Medical Center, Boston, MA, USA
8 Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
9 Department of Internal Medicine, Copenhagen University Hospital Gentofte, Copenhagen, Denmark
10 Stanford Prevention Research Center, Department of Medicine and Department of Health Research and Policy, Stanford University School of Medicine and Department of Statistics, Stanford University School of Humanities and Sciences, Stanford, CA, USA
11 Quantitative Sciences, Family Health International, Research Triangle Park, Durham, NC, USA
12 School Food Trust, Sheffield, UK
13 Ottawa Methods Centre, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada
14 Public Health Epidemiology and Biostatistics, School of Health and Population Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
* Corresponding author Email: jonathan.sterne@bristol.ac.uk
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