Coenzyme Q10 to manage chronic heart failure with a reduced ejection fraction: a systematic review and economic evaluation

Claxton, Lindsay; Simmonds, Mark; Beresford, Lucy; Cubbon, Richard; Dayer, Mark; Gottlieb, Stephen S; Hartshorne-Evans, Nick; Kilroy, Bruce; Llewellyn, Alexis; Rothery, Claire; Sharif, Sahar; Tierney, Jayne F; Witte, Klaus K; Wright, Kath; Stewart, Lesley A

doi:10.3310/KVOU6959

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This study suggested that co-Q10 has the potential to be clinically effective but concerns about the evidence base mean that a new trial is warranted.

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Lindsay Claxton ¹, Mark Simmonds ¹, Lucy Beresford ¹, Richard Cubbon ², Mark Dayer ³, Stephen S Gottlieb ⁴, Nick Hartshorne-Evans ⁵, Bruce Kilroy ⁶, Alexis Llewellyn ¹, Claire Rothery ⁷, Sahar Sharif ¹, Jayne F Tierney ⁸, Klaus K Witte ⁹, Kath Wright ¹, Lesley A Stewart ^1,^*

¹ Centre for Reviews and Dissemination, University of York, York, UK
² Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, UK
³ Department of Cardiology, Somerset NHS Foundation Trust, University of Exeter, Exeter, UK
⁴ School of Medicine, University of Maryland, College Park, MD, USA
⁵ The Pumping Marvellous Foundation, Preston, UK
⁶ , Harrogate, UK
⁷ Centre for Health Economics, University of York, York, UK
⁸ Medical Research Council Clinical Trials Unit, University College London, London, UK
⁹ School of Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, UK
^* Corresponding author Email: Lesley.stewart@york.ac.uk

Declared competing interests of authors: Richard Cubbon and Klaus K Witte have contributed to the ‘West Yorkshire’ database. Mark Dayer reports personal fees from Biotronik UK (Bicester, UK) outside the submitted work. Stephen S Gottlieb and Klaus K Witte were both principal investigators in one of the trials included in this systematic review.

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