Improving outcomes for women aged 70 years or above with early breast cancer: research programme including a cluster RCT

Wyld, Lynda; Reed, Malcolm WR; Collins, Karen; Ward, Sue; Holmes, Geoff; Morgan, Jenna; Bradburn, Mike; Walters, Stephen; Burton, Maria; Lifford, Kate; Edwards, Adrian; Brain, Kate; Ring, Alistair; Herbert, Esther; Robinson, Thompson G; Martin, Charlene; Chater, Tim; Pemberton, Kirsty; Shrestha, Anne; Nettleship, Anthony; Richards, Paul; Brennan, Alan; Cheung, Kwok Leung; Todd, Annaliza; Harder, Helena; Audisio, Riccardo; Battisti, Nicolo Matteo Luca; Wright, Juliet; Simcock, Richard; Murray, Christopher; Thompson, Alastair M; Gosney, Margot; Hatton, Matthew; Armitage, Fiona; Patnick, Julietta; Green, Tracy; Revill, Deirdre; Gath, Jacqui; Horgan, Kieran; Holcombe, Chris; Winter, Matt; Naik, Jay; Parmeshwar, Rishi

doi:10.3310/XZOE2552

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This research programme developed a fitness stratified decision tool to establish treatment thresholds and indicated that standard care was appropriate for the majority of fitter women aged 70 years or above.

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Lynda Wyld ^1,^2,^*, Malcolm WR Reed ³, Karen Collins ⁴, Sue Ward ⁵, Geoff Holmes ⁵, Jenna Morgan ^1,², Mike Bradburn ⁶, Stephen Walters ⁶, Maria Burton ⁴, Kate Lifford ⁷, Adrian Edwards ⁷, Kate Brain ⁷, Alistair Ring ⁸, Esther Herbert ⁶, Thompson G Robinson ⁹, Charlene Martin ^1,², Tim Chater ⁶, Kirsty Pemberton ⁶, Anne Shrestha ^1,², Anthony Nettleship ¹⁰, Paul Richards ⁵, Alan Brennan ⁵, Kwok Leung Cheung ¹¹, Annaliza Todd ^1,², Helena Harder ³, Riccardo Audisio ¹², Nicolo Matteo Luca Battisti ⁸, Juliet Wright ³, Richard Simcock ³, Christopher Murray ¹⁰, Alastair M Thompson ¹³, Margot Gosney ¹⁴, Matthew Hatton ¹⁵, Fiona Armitage ¹⁵, Julietta Patnick ¹⁶, Tracy Green ¹⁷, Deirdre Revill ¹⁷, Jacqui Gath ¹⁷, Kieran Horgan ¹⁸, Chris Holcombe ¹⁹, Matt Winter ¹⁵, Jay Naik ²⁰, Rishi Parmeshwar ²¹

¹ Department of Oncology and Metabolism, University of Sheffield Medical School, Sheffield, UK
² Jasmine Breast Centre, Doncaster and Bassetlaw Teaching Hospitals NHS Foundation Trust, Doncaster, UK
³ Brighton and Sussex Medical School, Brighton, UK
⁴ Faculty of Health and Wellbeing, Department of Allied Health Professions, Collegiate Cresent Campus, Sheffield Hallam University, Sheffield, UK
⁵ Department of Health and Social Care Economics and Decision Science, School for Health and Related Research, University of Sheffield, Sheffield, UK
⁶ Clinical Trials Research Unit, School for Health and Related Research, University of Sheffield, Sheffield, UK
⁷ Division of Population Medicine, School of Medicine, Cardiff University, Cardiff, UK
⁸ Breast Unit, Royal Marsden Hospital, London, UK
⁹ Department of Cardiovascular Sciences, University of Leicester, Cardiovascular Research Centre, Glenfield General Hospital, Leicester, UK
¹⁰ EpiGenesys, University of Sheffield, Sheffield, UK
¹¹ Breast Unit, Royal Derby Hospital, Derby, UK
¹² Sahlgrenska Universitetssjukhuset, University of Gothenburg, Göteborg, Sweden
¹³ Department of Surgery, Baylor College of Medicine, Houston, TX, USA
¹⁴ School of Psychology and Clinical Language Sciences, University of Reading, Reading, UK
¹⁵ Breast Unit, Weston Park Hospital, Sheffield, UK
¹⁶ Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK
¹⁷ Yorkshire and Humber Research Network Consumer Research Panel, Sheffield, UK
¹⁸ Breast Unit, Leeds General Infirmary, Leeds, UK
¹⁹ Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UK
²⁰ Breast Unit, Pinderfields Hospital, Mid Yorkshire Hospitals NHS Trust, Wakefield, UK
²¹ Breast Unit, Royal Lancaster Infirmary, University Hospitals of Morecambe Bay NHS Foundation Trust, Lancaster, UK
^* Corresponding author Email: L.wyld@sheffield.ac.uk

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