Optimal pharmacotherapy pathway in adults with diabetic peripheral neuropathic pain: the OPTION-DM RCT

Tesfaye, Solomon; Sloan, Gordon; Petrie, Jennifer; White, David; Bradburn, Mike; Young, Tracey; Rajbhandari, Satyan; Sharma, Sanjeev; Rayman, Gerry; Gouni, Ravikanth; Alam, Uazman; Julious, Steven A; Cooper, Cindy; Loban, Amanda; Sutherland, Katie; Glover, Rachel; Waterhouse, Simon; Turton, Emily; Horspool, Michelle; Gandhi, Rajiv; Maguire, Deirdre; Jude, Edward; Ahmed, Syed Haris; Vas, Prashanth; Hariman, Christian; McDougall, Claire; Devers, Marion; Tsatlidis, Vasileios; Johnson, Martin; Bouhassira, Didier; Bennett, David L; Selvarajah, Dinesh

doi:10.3310/RXUO6757

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This trial showed that the three commonly used treatment pathways in adults with diabetic peripheral neuropathic pain give comparable patient outcomes in a UK secondary care setting.

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Solomon Tesfaye ^1,^2,^*, Gordon Sloan ¹, Jennifer Petrie ³, David White ³, Mike Bradburn ³, Tracey Young ⁴, Satyan Rajbhandari ⁵, Sanjeev Sharma ⁶, Gerry Rayman ⁶, Ravikanth Gouni ⁷, Uazman Alam ^8,⁹, Steven A Julious ¹⁰, Cindy Cooper ³, Amanda Loban ³, Katie Sutherland ³, Rachel Glover ³, Simon Waterhouse ³, Emily Turton ³, Michelle Horspool ¹¹, Rajiv Gandhi ¹, Deirdre Maguire ¹², Edward Jude ^13,¹⁴, Syed Haris Ahmed ^8,¹⁵, Prashanth Vas ¹⁶, Christian Hariman ¹⁷, Claire McDougall ¹⁸, Marion Devers ¹⁹, Vasileios Tsatlidis ²⁰, Martin Johnson ²¹, Didier Bouhassira ²², David L Bennett ²³, Dinesh Selvarajah ²

¹ Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK
² Department of Oncology and Human Metabolism, Medical School, University of Sheffield, Sheffield, UK
³ Clinical Trials Research Unit, University of Sheffield, School of Health and Related Research (ScHARR), Sheffield, UK
⁴ School of Health and Related Research (ScHARR), University of Sheffield, Sheffield, UK
⁵ Lancashire Teaching Hospitals NHS Trust, Chorley, UK
⁶ East Suffolk and North Essex NHS Foundation Trust, Ipswich, UK
⁷ Nottingham University Hospitals NHS Trust, Nottingham, UK
⁸ University of Liverpool, Liverpool, UK
⁹ Liverpool University Hospital NHS Foundation Trust, Liverpool, UK
¹⁰ Medical Statistics Group, School of Health and Related Research (ScHARR), University of Sheffield, Sheffield, UK
¹¹ NHS Sheffield Clinical Commissioning Group, Sheffield, UK
¹² Harrogate and District NHS Foundation Trust, Harrogate, UK
¹³ Tameside and Glossop Integrated Care NHS Foundation Trust, Ashton under Lyne, UK
¹⁴ University of Manchester, Manchester, UK
¹⁵ Countess of Chester Hospital NHS Foundation Trust, Chester, UK
¹⁶ King’s College Hospital NHS Foundation Trust, London, UK
¹⁷ Royal Wolverhampton NHS Trust, Wolverhampton, UK
¹⁸ University Hospital Hairmyres, East Kilbride, UK
¹⁹ University Hospital Monklands, Airdrie, UK
²⁰ Gateshead Health NHS Foundation Trust, Gateshead, UK
²¹ hVIVO Services Limited, London, UK
²² Hospital Ambroise Paré, Paris, France
²³ Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
^* Corresponding author Email: solomon.tesfaye@nhs.net

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