Ondansetron and metoclopramide as second-line antiemetics in women with nausea and vomiting in pregnancy: the EMPOWER pilot factorial RCT

Robson, Stephen; McParlin, Catherine; Mossop, Helen; Lie, Mabel; Fernandez-Garcia, Cristina; Howel, Denise; Graham, Ruth; Ternent, Laura; Steel, Alison; Goudie, Nicola; Nadeem, Afnan; Phillipson, Julia; Shehmar, Manjeet; Simpson, Nigel; Tuffnell, Derek; Campbell, Ian; Williams, Rew; O’Hara, Margaret E; McColl, Elaine; Nelson-Piercy, Catherine

doi:10.3310/hta25630

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This trial was unable to meet the recruitment target due to unforeseen changes in provision of care and so was unable to provide evidence to support clinician decisions.

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Stephen Robson ^1,^*, Catherine McParlin ², Helen Mossop ¹, Mabel Lie ¹, Cristina Fernandez-Garcia ¹, Denise Howel ¹, Ruth Graham ³, Laura Ternent ¹, Alison Steel ⁴, Nicola Goudie ⁴, Afnan Nadeem ⁴, Julia Phillipson ⁴, Manjeet Shehmar ⁵, Nigel Simpson ⁶, Derek Tuffnell ⁷, Ian Campbell ⁸, Rew Williams ⁹, Margaret E O’Hara ⁹, Elaine McColl ¹, Catherine Nelson-Piercy ¹⁰

¹ Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
² Department of Nursing, Midwifery and Health, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, UK
³ School of Geography, Politics and Sociology, Newcastle University, Newcastle upon Tyne, UK
⁴ Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK
⁵ Gynaecology Secretaries Department, Birmingham Women’s and Children’s NHS Foundation Trust, Birmingham, UK
⁶ Leeds Institute of Medical Research, Department of Women’s and Children’s Health, School of Medicine, University of Leeds, Leeds, UK
⁷ Department of Obstetrics, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK
⁸ Pharmacy Department, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
⁹ Patient representative, ,
¹⁰ Department of Obstetric Medicine, Guy’s and St Thomas’ Foundation Trust, London, UK
^* Corresponding author Email: s.c.robson@ncl.ac.uk

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