A rapid intrapartum test for group B Streptococcus to reduce antibiotic usage in mothers with risk factors: the GBS2 cluster RCT

Daniels, Jane; Dixon, Emily F; Gill, Alicia; Bishop, Jon; D’Amico, Maria; Ahmed, Khaled; Dodds, Julie; Tryposkiadis, Kostas; Wilks, Mark; Millar, Michael; Husain, Shahid; Gray, Jim; Whiley, Angela; Moore, Patrick V; Munetsi, Ruvimbo L; Hemming, Karla; Roberts, Tracy; Plumb, Jane; Deeks, Jonathan; Khan, Khalid S; Thangaratinam, Shakila

doi:10.3310/BICF1187

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The rapid test did not reduce rates of antibiotic prophylaxis to prevent group B Streptococcus infection compared with usual care, but showed reasonable sensitivity and specificity.

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Jane Daniels ¹, Emily F Dixon ², Alicia Gill ², Jon Bishop ², Maria D’Amico ³, Khaled Ahmed ², Julie Dodds ³, Kostas Tryposkiadis ², Mark Wilks ⁴, Michael Millar ⁴, Shahid Husain ⁴, Jim Gray ⁵, Angela Whiley ⁴, Patrick V Moore ², Ruvimbo L Munetsi ², Karla Hemming ², Tracy Roberts ², Jane Plumb ⁶, Jonathan Deeks ², Khalid S Khan ⁴, Shakila Thangaratinam ^7,^*

¹ Nottingham Clinical Trials Unit, School of Medicine, University of Nottingham, Nottingham, UK
² Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
³ Centre for Women’s Health, Institute of Population Health Sciences, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
⁴ Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
⁵ Birmingham Women’s and Children’s NHS Foundation Trust, Birmingham, UK
⁶ Group B Strep Support, Haywards Heath, UK
⁷ Institute of Metabolism and System Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
^* Corresponding author Email: s.thangaratinam.1@bham.ac.uk

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