Reduced exposure to vasopressors through permissive hypotension to reduce mortality in critically ill people aged 65 and over: the 65 RCT

Mouncey, Paul R; Richards-Belle, Alvin; Thomas, Karen; Harrison, David A; Sadique, M Zia; Grieve, Richard D; Camsooksai, Julie; Darnell, Robert; Gordon, Anthony C; Henry, Doreen; Hudson, Nicholas; Mason, Alexina J; Saull, Michelle; Whitman, Chris; Young, J Duncan; Lamontagne, François; Rowan, Kathryn M; ,

doi:10.3310/hta25140

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Permissive hypotension did not significantly reduce mortality at 90 days compared to usual care, in critically ill people aged 65 and over receiving vasopressors for vasodilatory hypotension.

Paul R Mouncey , Alvin Richards-Belle , Karen Thomas , David A Harrison , M Zia Sadique , Richard D Grieve , Julie Camsooksai , Robert Darnell , Anthony C Gordon , Doreen Henry , Nicholas Hudson , Alexina J Mason , Michelle Saull , Chris Whitman , J Duncan Young , François Lamontagne , Kathryn M Rowan & .

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Paul R Mouncey ^1,^*, Alvin Richards-Belle ¹, Karen Thomas ¹, David A Harrison ¹, M Zia Sadique ², Richard D Grieve ², Julie Camsooksai ³, Robert Darnell ¹, Anthony C Gordon ^4,⁵, Doreen Henry ⁶, Nicholas Hudson ¹, Alexina J Mason ⁴, Michelle Saull ¹, Chris Whitman ⁶, J Duncan Young ⁷, François Lamontagne ^8,⁹, Kathryn M Rowan ¹, ^†

¹ Clinical Trials Unit, Intensive Care National Audit & Research Centre, London, UK
² Department of Health Services Research and Policy, London School of Hygiene & Tropical Medicine, London, UK
³ Critical Care, Research and Innovation, Poole Hospital NHS Foundation Trust, Poole, UK
⁴ Division of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, London, UK
⁵ Intensive Care Unit, Imperial College Healthcare NHS Trust, St Mary’s Hospital, London, UK
⁶ Patient representative, , UK
⁷ Kadoorie Centre for Critical Care Research and Education, University of Oxford, John Radcliffe Hospital, Oxford, UK
⁸ Department of Medicine, Université de Sherbrooke, Sherbrooke, QC, Canada
⁹ Centre de Recherche du Centre Hospitalier, Université de Sherbrooke, Sherbrooke, QC, Canada
^* Corresponding author Email: Paul.Mouncey@icnarc.org

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