Everolimus, lutetium-177 DOTATATE and sunitinib for advanced, unresectable or metastatic neuroendocrine tumours with disease progression: a systematic review and cost-effectiveness analysis

Mujica-Mota, Ruben; Varley-Campbell, Jo; Tikhonova, Irina; Cooper, Chris; Griffin, Ed; Haasova, Marcela; Peters, Jaime; Lucherini, Stefano; Talens-Bou, Juan; Long, Linda; Sherriff, David; Napier, Mark; Ramage, John; Hoyle, Martin

doi:10.3310/hta22490

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The RCT evidence showed clinical benefits from everolimus and sunitinib in neuroendocrine tumours, while the cost-effectiveness of the drugs ranged from about £20,000 to nearly £200,000 per QALY.

Ruben Mujica-Mota , Jo Varley-Campbell , Irina Tikhonova , Chris Cooper, Ed Griffin, Marcela Haasova, Jaime Peters, Stefano Lucherini , Juan Talens-Bou , Linda Long , David Sherriff , Mark Napier, John Ramage & Martin Hoyle .

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Ruben Mujica-Mota ^1,^*, Jo Varley-Campbell ¹, Irina Tikhonova ¹, Chris Cooper ¹, Ed Griffin ¹, Marcela Haasova ¹, Jaime Peters ¹, Stefano Lucherini ¹, Juan Talens-Bou ¹, Linda Long ¹, David Sherriff ², Mark Napier ³, John Ramage ⁴, Martin Hoyle ¹

¹ Peninsula Technology Assessment Group (PenTAG), University of Exeter, Exeter, UK
² Plymouth Oncology Centre, Plymouth Hospitals NHS Trust, Plymouth, UK
³ Exeter Oncology Centre, Royal Devon & Exeter NHS Foundation Trust, Exeter, UK
⁴ Neuroendocrine Tumour Service, King’s College Hospital NHS Foundation Trust, London, UK
^* Corresponding author Email: R.E.Mujica-Mota@exeter.ac.uk

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