A pilot randomised controlled trial of community-led ANtipsychotic Drug REduction for Adults with Learning Disabilities

McNamara, Rachel; Randell, Elizabeth; Gillespie, David; Wood, Fiona; Felce, David; Romeo, Renee; Angel, Lianna; Espinasse, Aude; Hood, Kerry; Davies, Amy; Meek, Andrea; Addison, Katy; Jones, Glyn; Deslandes, Paul; Allen, David; Knapp, Martin; Thapar, Ajay; Kerr, Michael

doi:10.3310/hta21470

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Planned as a full scale RCT, recruitment challenges meant the study was reported as a pilot and was terminated early; the limited results suggest that drug reduction is possible

Rachel McNamara, Elizabeth Randell, David Gillespie, Fiona Wood, David Felce, Renee Romeo, Lianna Angel, Aude Espinasse, Kerry Hood, Amy Davies, Andrea Meek, Katy Addison, Glyn Jones, Paul Deslandes, David Allen, Martin Knapp, Ajay Thapar & Michael Kerr.

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Rachel McNamara ¹, Elizabeth Randell ^1,^*, David Gillespie ¹, Fiona Wood ², David Felce ³, Renee Romeo ⁴, Lianna Angel ¹, Aude Espinasse ⁵, Kerry Hood ¹, Amy Davies ⁶, Andrea Meek ¹, Katy Addison ¹, Glyn Jones ³, Paul Deslandes ⁷, David Allen ^8,⁹, Martin Knapp ¹⁰, Ajay Thapar ³, Michael Kerr ³

¹ Centre for Trials Research, Cardiff University, Cardiff, UK
² Division of Population Medicine, Cardiff University, Cardiff, UK
³ Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK
⁴ Centre for the Economics of Mental Health, Institute of Psychiatry, King’s College London, London, UK
⁵ National Institute for Health Research Biomedical Research Centre – Clinical Trials Unit, Royal Marsden Hospital NHS Foundation Trust, Sutton, UK
⁶ Community Learning Disability Team, 2gether NHS Foundation Trust, Rotherwas, UK
⁷ Faculty of Life Sciences and Education, University of South Wales, Pontypridd, UK
⁸ The Tizard Centre, University of Kent, Canterbury, UK
⁹ Positive Response Training & Consultancy, Penryn, UK
¹⁰ Personal Social Services Research Unit, London School of Economics, London, UK
^* Corresponding author Email: randelle@cardiff.ac.uk

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