PET-NECK: a multicentre randomised Phase III non-inferiority trial comparing a positron emission tomography computerised tomography-guided  watch-and-wait policy with planned neck dissection in the management of locally advanced (N2/N3) nodal metastases in patients with squamous cell head and neck cancer

Mehanna, Hisham; McConkey, Chris C; Rahman, Joy K; Wong, Wai-Lup; Smith, Alison F; Nutting, Chris; Hartley, Andrew GJ; Hall, Peter; Hulme, Claire; Patel, Dharmesh K; Zeidler, Sandra Ventorin von; Robinson, Max; Sanghera, Bal; Fresco, Lydia; Dunn, Janet A

doi:10.3310/hta21170

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PET-CT guided active surveillance for locally advanced nodal metastases in head and neck cancer showed similar survival to planned neck dissection, with better quality of life and lower costs.

Hisham Mehanna, Chris C McConkey, Joy K Rahman, Wai-Lup Wong, Alison F Smith, Chris Nutting, Andrew GJ Hartley, Peter Hall, Claire Hulme, Dharmesh K Patel, Sandra Ventorin von Zeidler, Max Robinson, Bal Sanghera, Lydia Fresco & Janet A Dunn.

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Hisham Mehanna ^1,^*, Chris C McConkey ², Joy K Rahman ², Wai-Lup Wong ³, Alison F Smith ⁴, Chris Nutting ⁵, Andrew GJ Hartley ⁶, Peter Hall ⁴, Claire Hulme ⁴, Dharmesh K Patel ², Sandra Ventorin von Zeidler ⁷, Max Robinson ⁸, Bal Sanghera ³, Lydia Fresco ⁹, Janet A Dunn ²

¹ Institute of Head & Neck Studies and Education, University of Birmingham, Birmingham, UK
² Warwick Clinical Trials Unit, University of Warwick, Coventry, UK
³ Paul Strickland Scanner Centre, Mount Vernon Hospital, Northwood, UK
⁴ Academic Unit of Health Economics, University of Leeds, Leeds, UK
⁵ Royal Marsden Hospital, London, UK
⁶ University Hospital Birmingham, Birmingham, UK
⁷ Department of Pathology, Federal University of Espírito Santo, Vitória, Brazil
⁸ Centre for Oral Health Research, Newcastle University, Newcastle upon Tyne, UK
⁹ University Hospitals Coventry and Warwickshire, Coventry, UK
^* Corresponding author Email: H.Mehanna@bham.ac.uk

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