A pilot randomised controlled trial in intensive care patients comparing 7 days' treatment with empirical antibiotics with 2 days' treatment for hospital-acquired infection of unknown origin

Scawn, N; Saul, D; Pathak, D; Matata, B; Kemp, I; Stables, R; Lane, S; Haycox, A; Houten, R

doi:10.3310/hta16360

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Pilot study suggests that there could be significant benefits from reducing broad-spectrum antibiotic use in the intensive care unit without undermining patient safety, with potentially massive national overall resource savings, and that further investigation is warranted using a large randomised controlled trial.

N Scawn, D Saul, D Pathak, B Matata, I Kemp, R Stables, S Lane, A Haycox & R Houten.

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N Scawn ^1,^*, D Saul ¹, D Pathak ¹, B Matata ¹, I Kemp ¹, R Stables ¹, S Lane ², A Haycox ³, R Houten ³

¹ Liverpool Heart and Chest Hospital NHS Foundation Trust, Liverpool, UK
² Department of Biostatistics, University of Liverpool, Liverpool, UK
³ Liverpool School of Management, University of Liverpool, Liverpool, UK
^* Corresponding author Email: nigel.scawn@lhch.nhs.uk

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