A randomised placebo-controlled trial investigating efficacy and mechanisms of low-dose intradermal allergen immunotherapy in treatment of seasonal allergic rhinitis

Slovick, Anna; Douiri, Abdel; Muir, Rachel; Guerra, Andrea; Tsioulos, Konstantinos; Haye, Evie; Lam, Emily PS; Kelly, Joanna; Peacock, Janet L; Ying, Sun; Shamji, Mohamed H; Cousins, David J; Durham, Stephen R; Till, Stephen J

doi:10.3310/eme03100

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Low-dose intradermal immunotherapy for seasonal allergic rhinitis had no clinical effect even though it suppressed skin late responses to allergen.

Anna Slovick, Abdel Douiri, Rachel Muir, Andrea Guerra, Konstantinos Tsioulos, Evie Haye, Emily PS Lam, Joanna Kelly, Janet L Peacock, Sun Ying, Mohamed H Shamji, David J Cousins, Stephen R Durham & Stephen J Till.

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Anna Slovick ^1,², Abdel Douiri ³, Rachel Muir ⁴, Andrea Guerra ¹, Konstantinos Tsioulos ¹, Evie Haye ¹, Emily PS Lam ¹, Joanna Kelly ⁵, Janet L Peacock ³, Sun Ying ¹, Mohamed H Shamji ⁶, David J Cousins ^1,^2,⁷, Stephen R Durham ⁶, Stephen J Till ^1,^2,^*

¹ Division of Asthma, Allergy and Lung Biology, King’s College London, School of Medicine, Guy’s Hospital, London, UK
² Medical Research Council (MRC)–Asthma UK, Centre for Allergic Mechanisms of Asthma, London, UK
³ Division of Health and Social Care Research, King’s College London, London, UK
⁴ Clinical Research Facility, NIHR Biomedical Research Centre, Guy’s Hospital, London, UK
⁵ King’s Clinical Trials Unit, King’s College London, Institute of Psychiatry, London, UK
⁶ Allergy and Clinical Immunology, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, UK
⁷ Department of Infection, Immunity and Inflammation, National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Leicester Institute for Lung Health, University of Leicester, Leicester, UK
^* Corresponding author Email: stephen.till@kcl.ac.uk

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