Does metformin reduce excess birthweight in offspring of obese pregnant women? A randomised controlled trial of efficacy, exploration of mechanisms  and evaluation of other pregnancy complications

Chiswick, Carolyn A; Reynolds, Rebecca M; Denison, Fiona C; Drake, Amanda J; Forbes, Shareen; Newby, David E; Walker, Brian R; Quenby, Siobhan; Wray, Susan; Weeks, Andrew; Lashen, Hany; Rodriguez, Aryelly; Murray, Gordon D; Whyte, Sonia; Andrew, Ruth; Homer, Natalie; Semple, Scott; Gray, Calum; Aldhous, Marian C; Noble, Karen; Cunningham-Burley, Sarah; Keely, Alice; Norman, Jane E

doi:10.3310/eme03070

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Metformin taken by obese pregnant women did not reduce their baby's birthweight.

Carolyn A Chiswick, Rebecca M Reynolds, Fiona C Denison, Amanda J Drake, Shareen Forbes, David E Newby, Brian R Walker, Siobhan Quenby, Susan Wray, Andrew Weeks, Hany Lashen, Aryelly Rodriguez, Gordon D Murray, Sonia Whyte, Ruth Andrew, Natalie Homer, Scott Semple, Calum Gray, Marian C Aldhous, Karen Noble, Sarah Cunningham-Burley, Alice Keely & Jane E Norman.

Detailed Author information
Detailed Author information

Carolyn A Chiswick ¹, Rebecca M Reynolds ², Fiona C Denison ¹, Amanda J Drake ², Shareen Forbes ², David E Newby ², Brian R Walker ², Siobhan Quenby ³, Susan Wray ⁴, Andrew Weeks ⁵, Hany Lashen ⁶, Aryelly Rodriguez ⁷, Gordon D Murray ⁷, Sonia Whyte ¹, Ruth Andrew ², Natalie Homer ², Scott Semple ⁸, Calum Gray ⁸, Marian C Aldhous ¹, Karen Noble ⁹, Sarah Cunningham-Burley ⁷, Alice Keely ¹, Jane E Norman ^1,^*

¹ Tommy’s Centre for Fetal and Maternal Health, Medical Research Council Centre for Reproductive Health, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK
² University of Edinburgh/British Heart Foundation Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK
³ Department of Reproductive Health, Clinical Science Research Institute, Warwick Medical School, University Hospital, Coventry, UK
⁴ Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
⁵ Faculty of Health & Life Sciences, Liverpool Women’s Hospital, Liverpool, UK
⁶ Academic Unit of Reproductive and Developmental Medicine, University of Sheffield, Sheffield, UK
⁷ Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK
⁸ Clinical Research Imaging Centre, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK
⁹ School of Veterinary Science, University of Liverpool, Liverpool, UK
^* Corresponding author Email: jane.norman@ed.ac.uk

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