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HTA - 10/80/01
Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children - a review of unpublished data
Project title: Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children - a review of unpublished data
Call to action: 10/80 Cochrane Flu review
Research type: Evidence Synthesis
Chief investigator: Professor Carl Heneghan
Lead Author: Professor Carl Heneghan
Contractor: University of Oxford
Started: February 2011 | Status: Published May 2016
The study found that the neuraminidase inhibitors oseltamivir and zanamivir cause small reductions in the time to first alleviation of influenza symptoms in adults. Oseltamivir increases the risk of nausea, vomiting, psychiatric events in adults and vomiting in children and has no protective effect on mortality among patients with 2009A/H1N1 influenza.
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