Journals Library


HTA - 10/80/01

Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children - a review of unpublished data

Project title: Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children - a review of unpublished data

Call to action: 10/80 Cochrane Flu review

Research type: Evidence Synthesis

Chief investigator: Professor Carl Heneghan

Lead Author: Professor Carl Heneghan

Contractor: University of Oxford

Cost: £390,553.00

Co-investigators: Dr Mark Jones, Dr Matthew Thompson, Dr Rokuro Hama, Dr Thomas Jefferson, Mr Peter Doshi, Professor Chris Del Mar.

Started: February 2011 | Status: Published May 2016

The study found that the neuraminidase inhibitors oseltamivir and zanamivir cause small reductions in the time to first alleviation of influenza symptoms in adults. Oseltamivir increases the risk of nausea, vomiting, psychiatric events in adults and vomiting in children and has no protective effect on mortality among patients with 2009A/H1N1 influenza.

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Background & Research Questions

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Methods

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Results

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