Journals Library


HTA - 08/38/01

First trimester progesterone therapy in women with a history of unexplained recurrent miscarriages: A randomised, double-blind, placebo-controlled, multi-centre trial [The PROMISE (PROgesterone in recurrent MIScarriage) Trial]

Project title: First trimester progesterone therapy in women with a history of unexplained recurrent miscarriages: A randomised, double-blind, placebo-controlled, multi-centre trial [The PROMISE (PROgesterone in recurrent MIScarriage) Trial]

Call to action: 08/38 MRC Cross Cutting Board - 30th Jan 2008

Research type: Primary Research

Chief investigator: Dr Raj Rai

Lead Author: Professor Arri Coomarasamy

Contractor: Imperial College London

Cost: £1,083,872.64

Co-investigators: Dr Annette Briley, Dr Mariette Goddijn, Dr Nicholas Brook, Emeritus Professor Christine Godfrey, Mr Paul Seed, Mr Yacoub Khalaf, Professor Arri Coomarasamy, Professor Lesley Regan, Professor Mark Kilby, Professor Peter Braude, Professor Siobhan Quenby, Professor Tin-Chiu Li.

Started: October 2009 | Status: Published May 2016

ISRCTN: 92644181

The study found no evidence that first-trimester progesterone therapy improves outcomes in women with a history of unexplained recurrent miscarriages.

Links to project documentation

The links and documents below are related to this research and are added as and when they are produced over the life of the project. The information is provided by the researchers and some may have undergone varying editorial, production and publication models, which differ to NIHR Journals Library reports. Links are to both internal (NIHR) and external websites – the NIHR is not responsible for the content of external websites.

Background & Research Questions

Why the research is being done and what is being asked

Methods

How the research is being done

Results

What the research found

Impact

What impact the research has had

If you would like to receive a notification when this project is updated, please submit your email address below.