HTA - 15/80/40

Risk-benefit and costs of unicompartmental (compared to total) knee replacement for patients with multiple co-morbidities: a non-randomised study, and different novel approaches to minimise confounding.

Project title: Risk-benefit and costs of unicompartmental (compared to total) knee replacement for patients with multiple co-morbidities: a non-randomised study, and different novel approaches to minimise confounding.

Call to action: 15/80 15/80 HTA Efficient Study Designs

Research type: Primary Research

Chief investigator: Professor Daniel Prieto-Alhambra

Lead Author: Professor Daniel Prieto-Alhambra

Contractor: University of Oxford

Cost: £268,076.76

Co-investigators: Associate Professor Rafael Pinedo-Villanueva, Ms Susan Thwaite, Professor Alan Silman, Professor Andrew Carr, Professor Andrew Judge, Professor David Beard, Professor David Murray, Professor Ian Douglas, Professor Irene Petersen, Professor Jeremy Wilkinson, Professor Jose M Valderas, Professor Nigel Arden, Professor Sarah Lamb.

Started: June 2017 | Status: Published November 2021

This study confirmed the results of the TOPKAT study and unicompartmental knee replacement was safer and less expensive than total knee replacement for patients with severe comorbidity.

Links to project documentation

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