Journals Library


HTA - 15/80/40

Risk-benefit and costs of unicompartmental (compared to total) knee replacement for patients with multiple co-morbidities: a non-randomised study, and different novel approaches to minimise confounding.

Project title: Risk-benefit and costs of unicompartmental (compared to total) knee replacement for patients with multiple co-morbidities: a non-randomised study, and different novel approaches to minimise confounding.

Call to action: 15/80 15/80 HTA Efficient Study Designs

Research type: Primary Research

Chief investigator: Professor Daniel Prieto-AlhambraORCID logo

Lead Author: Professor Daniel Prieto-AlhambraORCID logo

Contractor: University of Oxford

Cost: £268,076.76

Co-investigators: Associate Professor Rafael Pinedo-VillanuevaORCID logo, Ms Susan Thwaite, Professor Alan SilmanORCID logo, Professor Andrew CarrORCID logo, Professor Andrew JudgeORCID logo, Professor David BeardORCID logo, Professor David MurrayORCID logo, Professor Ian DouglasORCID logo, Professor Irene PetersenORCID logo, Professor Jeremy WilkinsonORCID logo, Professor Jose M ValderasORCID logo, Professor Nigel ArdenORCID logo, Professor Sarah LambORCID logo.

Started: June 2017 | Status: Published November 2021

This study confirmed the results of the TOPKAT study and unicompartmental knee replacement was safer and less expensive than total knee replacement for patients with severe comorbidity.

Links to project documentation

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Background & Research Questions

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