Journals Library

HTA - 14/190/01

The CRASH-3 Trial: Tranexamic acid for the treatment of significant traumatic brain injury

Project title: The CRASH-3 Trial: Tranexamic acid for the treatment of significant traumatic brain injury

Call to action: 14/190 14/190 CRASH 3 : Tranexamic acid trial MRC / HTA joint fund 2014

Research type: Primary Research

Chief investigator: Professor Ian RobertsORCID logo

Lead Author: Professor Ian RobertsORCID logo

Contractor: London School of Hygiene & Tropical Medicine

Cost: £1,234,340.75

Co-investigators: Dr Katharine KerORCID logo, Professor Adeniran Fawole, Professor Antonio BelliORCID logo, Professor Haleema Shakur-StillORCID logo, Professor Matthew ShokunbiORCID logo, Professor Rashid JoomaORCID logo, Professor Rizwana ChaudhriORCID logo, Professor Tim HarrisORCID logo.

Started: October 2014 | Status: Published April 2021

ISRCTN: 15088122

Tranexamic acid was safe in patients with traumatic brain injury and treatment within 3 hours of injury reduced head injury-related death, with a cost/QALY of £4300 in those with mild or moderate head injury.

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Background & Research Questions

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