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HTA - 14/190/01
The CRASH-3 Trial: Tranexamic acid for the treatment of significant traumatic brain injury
Project title: The CRASH-3 Trial: Tranexamic acid for the treatment of significant traumatic brain injury
Call to action: 14/190 14/190 CRASH 3 : Tranexamic acid trial MRC / HTA joint fund 2014
Research type: Primary Research
Chief investigator: Professor Ian Roberts
Lead Author: Professor Ian Roberts
Contractor: London School of Hygiene & Tropical Medicine
Co-investigators: Dr Katharine Ker, Professor Adeniran Fawole, Professor Antonio Belli, Professor Haleema Shakur-Still, Professor Matthew Shokunbi, Professor Rashid Jooma, Professor Rizwana Chaudhri, Professor Tim Harris.
Started: October 2014 | Status: Published April 2021
Tranexamic acid was safe in patients with traumatic brain injury and treatment within 3 hours of injury reduced head injury-related death, with a cost/QALY of £4300 in those with mild or moderate head injury.
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