Journals Library

HTA - 13/115/48

Antidepressants to prevent relapse in depression

Project title: Antidepressants to prevent relapse in depression

Call to action: 14/08 14/08 HTA CET Open Call, Outline to Full Form

Research type: Primary Research

Chief investigator: Professor Glyn LewisORCID logo

Lead Author: Ms Larisa DuffyORCID logo

Contractor: University College London

Cost: £1,807,618.00

Co-investigators: Dr Rachael HunterORCID logo, Professor Anthony KendrickORCID logo, Professor David KesslerORCID logo, Professor Irwin NazarethORCID logo, Professor Michael KingORCID logo, Professor Michael MooreORCID logo, Professor Nick FreemantleORCID logo, Professor Nicola WilesORCID logo, Professor Simon GilbodyORCID logo.

Started: May 2016 | Status: Published November 2021

ISRCTN: 15969819

This trial showed patients who discontinue long-term maintenance antidepressants are at increased risk of relapse and withdrawal symptoms, however, a substantial proportion of patients can discontinue antidepressants without relapse.

Links to project documentation

The links and documents below are related to this research and are added as and when they are produced over the life of the project. The information is provided by the researchers and some may have undergone varying editorial, production and publication models, which differ to NIHR Journals Library reports. Links are to both internal (NIHR) and external websites – the NIHR is not responsible for the content of external websites.

Background & Research Questions

Why the research is being done and what is being asked


How the research is being done

Publications & Outputs

What the research produced

Outcomes & Impact

What happened as a result of the research

If you would like to receive a notification when this project is updated, please submit your email address below. This will also notify you when the Journals Library report is published.