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HTA - 12/33/12

Primary care use of a C-Reactive Protein (CRP) Point of Care Test (POCT) to help target antibiotic prescribing to patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) who are most likely to benefit (The PACE Study)

Project title: Primary care use of a C-Reactive Protein (CRP) Point of Care Test (POCT) to help target antibiotic prescribing to patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) who are most likely to benefit (The PACE Study)

Call to action: 13/88 13/88 Anti-microbial Resistance Themed Call

Research type: Primary Research

Chief investigator: Professor Christopher ButlerORCID logo

Lead Author: Professor Nick FrancisORCID logo

Contractor: Cardiff University

Cost: £1,373,574.21

Co-investigators: Dr Carl LlorORCID logo, Dr David GillespieORCID logo, Dr Gurudutt NaikORCID logo, Dr Jacqueline Nuttall, Dr Jochen CalsORCID logo, Dr Mandy WoottonORCID logo, Dr Micaela GalORCID logo, Dr Patrick WhiteORCID logo, Dr Rhiannon PhillipsORCID logo, Dr Robin Howe, Mrs Margaret Barnard, Professor Brendan DelaneyORCID logo, Professor David Cohen, Professor Hasse MelbyeORCID logo, Professor Kerenza HoodORCID logo, Professor Nick FrancisORCID logo.

Started: July 2014 | Status: Published March 2020

ISRCTN: 24346473

Point-of-care testing resulted in a 20% absolute reduction in patient-reported antibiotic consumption over 4 weeks, without impairing chronic obstructive pulmonary disease health status.

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