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HTA - 12/167/26
Effectiveness of progesterone to prevent miscarriage in women with early pregnancy bleeding: A randomised placebo-controlled trial (PRISM Trial: PRogesterone In Spontaneous Miscarriage Trial)
Project title: Effectiveness of progesterone to prevent miscarriage in women with early pregnancy bleeding: A randomised placebo-controlled trial (PRISM Trial: PRogesterone In Spontaneous Miscarriage Trial)
Call to action: 12/167 12/167 HTA CET Open Call, Outline Form
Research type: Primary Research
Contractor: University of Birmingham
Co-investigators: Associate Professor Nicholas Raine-Fenning, Dr Caroline Overton, Dr Cecilia Bottomley, Dr Davor Jurkovic, Dr Feroza Dawood, Dr Hoda Harb, Dr Kim Hinshaw, Dr Pratima Gupta, Dr Roy Farquharson, Dr William Duncan, Mr Lee Middleton, Ms Ruth Bender Atik, Professor Andrew Horne, Professor Jane Daniels, Professor Jane Norman, Professor Mary Ann Lumsden, Professor Siobhan Quenby, Professor Thomas Bourne, Professor Tracy Roberts.
Started: October 2014 | Status: Published July 2020
Progesterone in the first trimester did not result in a higher rate of live births, but a subgroup analysis suggested some effect in women with more previous miscarriages.
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