Journals Library


HTA - 09/23/01

Literature review of the effectiveness and safety of prophylactic treatment for the ocular manifestations of stickler syndrome

Project title: Literature review of the effectiveness and safety of prophylactic treatment for the ocular manifestations of stickler syndrome

Call to action: 09/23 Can prophylactic surgery reduce the risk of retinal detachment and blindness in Stickler syndrome, especially in children?

Research type: Evidence Synthesis

Chief investigator: Dr Christopher CarrollORCID logoorcid.org/0000-0002-6361-6182

Lead Author: Dr Christopher CarrollORCID logoorcid.org/0000-0002-6361-6182

Contractor: The University of Sheffield

Started: August 2009 | Status: Published April 2011

Only 360 deg; cryotherapy and focal and circumferential laser treatment have been evaluated for the type 1 Stickler syndrome population, and then only by a single retrospective, controlled, cohort study in each case. Both of these studies report a significant difference between intervention and control groups (principally no treatment) and no major or long-term side effects or complications. However, there is a high risk of bias within these two studies, so the relative effectiveness of either intervention is uncertain

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