Journals Library


HTA - 08/70/01

An evaluation of the feasibility, cost and value of information of a multicentre randomised controlled trial of intravenous immunoglobulin for sepsis (severe sepsis and septic shock)

Project title: An evaluation of the feasibility, cost and value of information of a multicentre randomised controlled trial of intravenous immunoglobulin for sepsis (severe sepsis and septic shock)

Call to action: 08/70 Intravenous immunoglobulin for sepsis

Research type: Evidence Synthesis

Chief investigator: Professor Kathryn RowanORCID logoorcid.org/0000-0001-8217-5602

Lead Author: Dr Marta Soares

Contractor: Intensive Care National Audit & Research Centre

Cost: £126,799.00

Co-investigators: Professor Anthony Ades, Professor David Harrison, Professor Graham Ramsay, Professor Mervyn Singer, Professor Nicky Welton, Professor Richard Beale, Professor Stephen Palmer, Professor W Sewell.

Started: May 2009 | Status: Published February 2012

Study found treatment effect of intravenous immunoglobulin on mortality for patients with severe sepsis is borderline significant with a large degree of heterogeneity in the treatment effect between individual studies.

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