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HTA - 08/227/01
Intensity modulated radiotherapy for the treatment of prostate cancer: a systematic review and economic evaluation
Project title: Intensity modulated radiotherapy for the treatment of prostate cancer: a systematic review and economic evaluation
Call to action: 14/99 HTA Technology Assessment Reports
Research type: Evidence Synthesis
Lead Author: Ms Silvia Hummel
Contractor: The University of Sheffield
Co-investigators: Ms Silvia Hummel.
Started: December 2008 | Status: Published October 2010
Study found that higher doses of intensity-modulated radiotherapy (IMRT), up to 81 Gy, can improve biochemical survival for patients with localised prostate cancer. Data also suggest that toxicity can be reduced by increasing conformality of treatment, particularly with regard to gastrointestinal (GI) toxicity, which can be more easily achieved with IMRT than three-dimensional conformal radiotherapy (3DCRT). Whether differences in GI toxicity between IMRT and 3DCRT are sufficient for IMRT to be cost-effective is uncertain, depending on the difference in incidence of GI toxicity, its duration and the cost difference between IMRT and 3DCRT
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