Journals Library


HTA - 08/227/01

Intensity modulated radiotherapy for the treatment of prostate cancer: a systematic review and economic evaluation

Project title: Intensity modulated radiotherapy for the treatment of prostate cancer: a systematic review and economic evaluation

Call to action: 14/99 HTA Technology Assessment Reports

Research type: Evidence Synthesis

Chief investigator: Professor Eva KaltenthalerORCID logoorcid.org/0000-0002-6185-8321

Lead Author: Ms Silvia Hummel

Contractor: The University of Sheffield

Co-investigators: Ms Silvia Hummel.

Started: December 2008 | Status: Published October 2010

Study found that higher doses of intensity-modulated radiotherapy (IMRT), up to 81 Gy, can improve biochemical survival for patients with localised prostate cancer. Data also suggest that toxicity can be reduced by increasing conformality of treatment, particularly with regard to gastrointestinal (GI) toxicity, which can be more easily achieved with IMRT than three-dimensional conformal radiotherapy (3DCRT). Whether differences in GI toxicity between IMRT and 3DCRT are sufficient for IMRT to be cost-effective is uncertain, depending on the difference in incidence of GI toxicity, its duration and the cost difference between IMRT and 3DCRT

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