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HTA - 07/05/01

Pregnancy - routine anti-D prophylaxis for rhesus negative women (review) (update of NICE Guidance 41 with inclusion of a new drug - rhophylac)

Project title: Pregnancy - routine anti-D prophylaxis for rhesus negative women (review) (update of NICE Guidance 41 with inclusion of a new drug - rhophylac)

Call to action: 14/104 NICE 13th wave MTA

Chief investigator: Dr Hazel SquiresORCID logoorcid.org/0000-0002-2776-4014

Lead Author: Dr Hazel Squires

Contractor: The University of Sheffield

Started: August 2007 | Status: Published February 2009

Study found that routine antenatal anti-D prophylaxis reduces the incidence of sensitisation in Rhesus D-negative pregnant women, and hence of haemolytic disease of the newborn. Its use in all Rhesus D-negative pregnant women is estimated to have a cost per quality-adjusted life-year gained of less than £35,000 for all regimens compared with not offering routine anti-D or limiting its use to Rhesus D-negative primigravidae

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