Journals Library


HTA - 06/403/51

A randomised controlled trial to compare the safety and effectiveness of doxycycline (200 mg/day) with prednisolone (0.5 mg/kg/day) for initial treatment of bullous pemphigoid

Project title: A randomised controlled trial to compare the safety and effectiveness of doxycycline (200 mg/day) with prednisolone (0.5 mg/kg/day) for initial treatment of bullous pemphigoid

Call to action: 06/403 HTA Clinical Trials - Pharmaceutical Panel - September 2006

Research type: Primary Research

Chief investigator: Professor Hywel WilliamsORCID logo https://orcid.org/0000-0002-5646-3093

Lead Author: Dr Joanne Chalmers

Contractor: The University of Nottingham

Cost: £861,317.98

Co-investigators: Dr Gudula Kirtschig, Dr Joanne Chalmers, Professor Andrew Nunn, Professor Fenella Wojnarowska, Professor James Mason.

Started: October 2008 | Status: Published March 2017

ISRCTN: 13704604

The study found that a strategy of starting bullous pemphigoid patients on doxycycline is non-inferior to standard treatment with oral prednisolone for short-term blister control and considerably safer in the long term.

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