Journals Library


HTA - 06/303/20

CRASH2 Trial, a large randomised placebo controlled trial among trauma patients with significant haemorrhage of the effects of an antifibrinolytic treatment on death and transfusion requirement

Project title: CRASH2 Trial, a large randomised placebo controlled trial among trauma patients with significant haemorrhage of the effects of an antifibrinolytic treatment on death and transfusion requirement

Call to action: 06/303 HTA Clinical Trials - Pharmaceutical Panel

Research type: Primary Research

Chief investigator: Professor Ian RobertsORCID logoorcid.org/0000-0003-1596-6054

Lead Author: Professor Ian RobertsORCID logoorcid.org/0000-0003-1596-6054

Contractor: London School of Hygiene & Tropical Medicine

Cost: £2,545,661.00

Co-investigators: Professor Beverley Hunt, Professor Haleema Shakur-Still, Professor Timothy Coats.

Started: April 2007 | Status: Published March 2013

ISRCTN: 86750102

Study to evaluate the effect of tranexamic acid in traumatic brain injury patients found that neither moderate benefits nor moderate harmful effects can be excluded and that, although uncertainty remains, tranexamic administration might improve outcome in traumatic brain injury patients.

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