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HTA - 02/06/02
Long-term randomised controlled trial in primary care of the effectiveness and cost-effectiveness of levonorgestrel containing coil (Mirena) against standard treatment for menorrhagia: LAST trial
Project title: Long-term randomised controlled trial in primary care of the effectiveness and cost-effectiveness of levonorgestrel containing coil (Mirena) against standard treatment for menorrhagia: LAST trial
Call to action: 02/06 Intra-uterine systems containing levenorgestrel in the treatment of menorrhagia
Research type: Primary Research
Chief investigator: Professor Janesh Gupta
Lead Author: Professor Janesh Gupta
Contractor: University of Birmingham
Co-investigators: Dr Carole Cummins, Professor Helen Pattison, Professor Jane Daniels, Professor Joe Kai, Professor Khalid Khan, Professor Richard Gray, Professor Richard Lilford, Professor Robert Shaw, Professor Stirling Bryan.
Started: November 2004 | Status: Published October 2015
The study found that the levonorgestrel-releasing intrauterine system (LNG-IUS) leads to greater improvement compared with usual medical therapies over 2 years in women’s assessments of the effect of heavy menstrual bleeding (HMB) on their daily routine, including work, social and family life, and psychological and physical well-being. These findings were no longer significantly different at 5 years. In the primary care setting, treating HMB using the LNG-IUS costs more, but is also more effective, using the EQ-5D as the outcome, than usual medical treatment in both the short and medium term.
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