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The research programme has improved our understanding of when patients experience improvement and found that sertraline did not reduce depressive symptoms at 6 weeks but did reduce anxiety symptoms.

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Larisa Duffy 1,*, Gemma Lewis 1, Anthony Ades 2, Ricardo Araya 3, Jessica Bone 1, Sally Brabyn 4, Katherine Button 5, Rachel Churchill 6, Tim Croudace 7, Catherine Derrick 2, Padraig Dixon 2, Christopher Dowrick 8, Christopher Fawsitt 2, Louise Fusco 8, Simon Gilbody 4, Catherine Harmer 9, Catherine Hobbs 5, William Hollingworth 2, Vivien Jones 2, Tony Kendrick 10, David Kessler 2, Naila Khan 8, Daphne Kounali 2, Paul Lanham 11, Alice Malpass 2, Marcus Munafo 12, Jodi Pervin 4, Tim Peters 2, Derek Riozzie 11, Jude Robinson 13, George Salaminios 1, Debbie Sharp 2, Howard Thom 2, Laura Thomas 2, Nicky Welton 2, Nicola Wiles 2, Rebecca Woodhouse 4, Glyn Lewis 1

1 Division of Psychiatry, University College London, London, UK
2 Bristol Medical School, University of Bristol, Bristol, UK
3 Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
4 Department of Health Sciences, University of York, York, UK
5 Department of Psychology, University of Bath, Bath, UK
6 Centre for Reviews and Dissemination, University of York, York, UK
7 School of Nursing and Health Studies, University of Dundee, Dundee, UK
8 Institute of Psychology Health and Society, University of Liverpool, Liverpool, UK
9 Department of Psychiatry, University of Oxford, Oxford, UK
10 Primary Care and Population Sciences, Faculty of Medicine, University of Southampton, Southampton, UK
11 Patient and public involvement contributor, , UK
12 Department of Psychology and Integrated Epidemiology Unit, University of Bristol, Bristol, UK
13 Department of Sociology, Social Policy and Criminology, University of Liverpool, Liverpool, UK
* Corresponding author Email:

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