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This biomarker programme synthesised a research framework for patient monitoring, reviewed RCTs, created a prospective sample and data banking system and completed and reported initial outcomes for a large RCT.

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Peter J Selby 1,2,*, Rosamonde E Banks 1, Walter Gregory 3, Jenny Hewison 4, William Rosenberg 5, Douglas G Altman 6, Jonathan J Deeks 7, Christopher McCabe 8, Julie Parkes 9, Catharine Sturgeon 10, Douglas Thompson 2, Maureen Twiddy 4, Janine Bestall 4, Joan Bedlington 11, Tilly Hale 11,, Jacqueline Dinnes 7, Marc Jones 3, Andrew Lewington 2, Michael P Messenger 2, Vicky Napp 3, Alice Sitch 7, Sudeep Tanwar 5, Naveen S Vasudev 1,2, Paul Baxter 12, Sue Bell 3, David A Cairns 1, Nicola Calder 2, Neil Corrigan 3, Francesco Del Galdo 13, Peter Heudtlass 3, Nick Hornigold 1, Claire Hulme 4, Michelle Hutchinson 1, Carys Lippiatt 14, Tobias Livingstone 2, Roberta Longo 4, Matthew Potton 3, Stephanie Roberts 1, Sheryl Sim 1, Sebastian Trainor 1, Matthew Welberry Smith 1,2, James Neuberger 15, Douglas Thorburn 16, Paul Richardson 17, John Christie 18, Neil Sheerin 19, William McKane 20, Paul Gibbs 21, Anusha Edwards 22, Naeem Soomro 19, Adebanji Adeyoju 23, Grant D Stewart 24,25, David Hrouda 26

1 Clinical and Biomedical Proteomics Group, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK
2 Leeds Teaching Hospitals NHS Trust, Leeds, UK
3 Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK
4 Leeds Institute of Health Sciences, University of Leeds, Leeds, UK
5 Institute for Liver and Digestive Health, Division of Medicine, University College London, London, UK
6 Centre for Statistics in Medicine, University of Oxford, Oxford, UK
7 Institute of Applied Health Research, University of Birmingham, Birmingham, UK
8 Department of Emergency Medicine, University of Alberta Hospital, Edmonton, AB, Canada
9 Primary Care and Population Sciences Academic Unit, University of Southampton, Southampton, UK
10 Royal Infirmary of Edinburgh, Edinburgh, UK
11 LIVErNORTH Liver Patient Support, Newcastle upon Tyne, UK
12 Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK
13 Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK
14 Department of Specialist Laboratory Medicine, Leeds Teaching Hospitals NHS Trust, Leeds, UK
15 University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
16 Royal Free London NHS Foundation Trust, London, UK
17 Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UK
18 Royal Devon and Exeter NHS Foundation Trust, Exeter, UK
19 Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
20 Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK
21 Portsmouth Hospitals NHS Trust, Portsmouth, UK
22 North Bristol NHS Trust, Bristol, UK
23 Stockport NHS Foundation Trust, Stockport, UK
24 NHS Lothian, Edinburgh, UK
25 Academic Urology Group, University of Cambridge, Cambridge, UK
26 Charing Cross Hospital, Imperial College Healthcare NHS Trust, London, UK
* Corresponding author Email: p.j.selby@leeds.ac.uk

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