13/89/09 - Safe and appropriate use of blood components

Research type: Evidence Synthesis

Start date: July 2014

Publication date: July 2018

Cost: £299,999.00

Contractor: NHS Blood and Transplant 

Publications 

• Alternatives, and adjuncts, to prophylactic platelet transfusion for people with haematological malignancies undergoing intensive chemotherapy or stem cell transplantation
• Alternative agents to prophylactic platelet transfusion for preventing bleeding in people with thrombocytopenia due to chronic bone marrow failure: a meta-analysis and systematic review
• Antifibrinolytics (lysine analogues) for the prevention of bleeding in people with haematological disorders
• Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease
• Comparison of different platelet transfusion thresholds prior to insertion of central lines in patients with thrombocytopenia
• Comparison of different platelet count thresholds to guide administration of prophylactic platelet transfusion for preventing bleeding in people with haematological disorders after myelosuppressive chemotherapy or stem cell transplantation 
• Comparison of a restrictive versus liberal red cell transfusion policy for patients with myelodysplasia, aplastic anaemia, and other congenital bone marrow failure disorders 
• Different doses of prophylactic platelet transfusion for preventing bleeding in people with haematological disorders after myelosuppressive chemotherapy or stem cell transplantation
• Granulocyte transfusions for preventing infections in people with neutropenia or neutrophil dysfunction
• Granulocyte transfusions for treating infections in people with neutropenia or neutrophil dysfunction
• Interventions for preventing silent cerebral infarcts in people with sickle cell disease
• Plasma transfusions prior to lumbar punctures and epidural catheters for people with abnormal coagulation
• Plasma transfusions prior to insertion of central lines for people with abnormal coagulation
• Preoperative blood transfusions for sickle cell disease
• Regular long-term red blood cell transfusions for managing chronic chest complications in sickle cell disease
• Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem cell support
• Use of platelet transfusions prior to lumbar punctures or epidural anaesthesia for the prevention of complications in people with thrombocytopenia