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Tranexamic acid was safe in patients with traumatic brain injury and treatment within 3 hours of injury reduced head injury-related death, with a cost/QALY of £4300 in those with mild or moderate head injury.

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Ian Roberts 1,*, Haleema Shakur-Still 1, Amy Aeron-Thomas 2, Danielle Beaumont 1, Antonio Belli 3, Amy Brenner 1, Madeleine Cargill 1, Rizwana Chaudhri 4, Nicolas Douglas 5, Lauren Frimley 1, Catherine Gilliam 1, Amber Geer 1, Zahra Jamal 1, Rashid Jooma 6, Raoul Mansukhani 1, Alec Miners 5, Jason Pott 7, Danielle Prowse 1, Temitayo Shokunbi 8, Jack Williams 5

1 Clinical Trials Unit, London School of Hygiene & Tropical Medicine, London, UK
2 RoadPeace, London, UK
3 National Institute for Health Research Surgical Reconstruction and Microbiology Research Centre, Queen Elizabeth Hospital, Birmingham, UK
4 Department of Obstetrics and Gynaecology, Rawalpindi Medical University, Rawalpinidi, Pakistan
5 Department of Health Services Research and Policy, London School of Hygiene & Tropical Medicine, London, UK
6 Department of Surgery, The Aga Khan University Medical College, Karachi, Pakistan
7 Emergency Department, Barts Health NHS Trust, The Royal London Hospital, London, UK
8 Department of Anatomy and Surgery, University of Ibadan, Ibadan, Nigeria
* Corresponding author Email: Ian.Roberts@lshtm.ac.uk

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