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This trial found that 3.2% of people treated with adrenaline following out-of-hospital cardiac arrest survived to 30 days, compared with 2.4% of people receiving placebo.

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Gavin D Perkins 1,2,*, Chen Ji 1, Felix Achana 1, John JM Black 3, Karl Charlton 4, James Crawford 1, Adam de Paeztron 1, Charles Deakin 5, Mark Docherty 6, Judith Finn 7, Rachael T Fothergill 8, Simon Gates 9, Imogen Gunson 6, Kyee Han 4, Susie Hennings 1, Jessica Horton 1, Kamran Khan 1, Sarah Lamb 1, John Long 10, Joshua Miller 6, Fionna Moore 11, Jerry Nolan 1,12, Lyndsey O’Shea 13, Stavros Petrou 1, Helen Pocock 3, Tom Quinn 14, Nigel Rees 13, Scott Regan 1, Andy Rosser 6, Charlotte Scomparin 1, Anne Slowther 1, Ranjit Lall 1

1 Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK
2 Heartlands Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
3 South Central Ambulance Service NHS Foundation Trust, Bicester, UK
4 North East Ambulance Service NHS Foundation Trust, Newcastle upon Tyne, UK
5 Southampton University Hospital, Southampton, UK
6 West Midlands Ambulance Service University NHS Foundation Trust, Brierley Hill, UK
7 Prehospital, Resuscitation and Emergency Care Research Unit (PRECRU), Curtin University, Perth, WA, Australia
8 London Ambulance Service NHS Trust, London, UK
9 Cancer Research Clinical Trials Unit (CRCTU), University of Birmingham, Birmingham, UK
10 Patient and Public Involvement Representative, Warwick, UK
11 South East Coast Ambulance Service NHS Foundation Trust, Crawley, UK
12 Royal United Hospitals Bath NHS Foundation Trust, Bath, UK
13 Welsh Ambulance Service NHS Trust, St Asaph, UK
14 Emergency, Cardiovascular and Critical Care Research Group, Faculty of Health, Social Care and Education, Kingston University London and St George’s, University of London, London, UK
* Corresponding author Email: G.D.Perkins@warwick.ac.uk

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