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Permissive hypotension did not significantly reduce mortality at 90 days compared to usual care, in critically ill people aged 65 and over receiving vasopressors for vasodilatory hypotension.

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Paul R Mouncey 1,*, Alvin Richards-Belle 1, Karen Thomas 1, David A Harrison 1, M Zia Sadique 2, Richard D Grieve 2, Julie Camsooksai 3, Robert Darnell 1, Anthony C Gordon 4,5, Doreen Henry 6, Nicholas Hudson 1, Alexina J Mason 4, Michelle Saull 1, Chris Whitman 6, J Duncan Young 7, François Lamontagne 8,9, Kathryn M Rowan 1,

1 Clinical Trials Unit, Intensive Care National Audit & Research Centre, London, UK
2 Department of Health Services Research and Policy, London School of Hygiene & Tropical Medicine, London, UK
3 Critical Care, Research and Innovation, Poole Hospital NHS Foundation Trust, Poole, UK
4 Division of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, London, UK
5 Intensive Care Unit, Imperial College Healthcare NHS Trust, St Mary’s Hospital, London, UK
6 Patient representative, , UK
7 Kadoorie Centre for Critical Care Research and Education, University of Oxford, John Radcliffe Hospital, Oxford, UK
8 Department of Medicine, Université de Sherbrooke, Sherbrooke, QC, Canada
9 Centre de Recherche du Centre Hospitalier, Université de Sherbrooke, Sherbrooke, QC, Canada
* Corresponding author Email:

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