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This study suggested that a multicentre trial comparing the effectiveness of broad-spectrum antibiotics and active observation to appendicectomy is feasible.

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Nigel J Hall, Frances C Sherratt, Simon Eaton, Isabel Reading, Erin Walker, Maria Chorozoglou, Lucy Beasant, Wendy Wood, Michael Stanton, Harriet J Corbett, Dean Rex, Natalie Hutchings, Elizabeth Dixon, Simon Grist, William van’t Hoff, Esther Crawley, Jane Blazeby & Bridget Young.

Nigel J Hall 1,*, Frances C Sherratt 2, Simon Eaton 3, Isabel Reading 4, Erin Walker 5, Maria Chorozoglou 6, Lucy Beasant 7, Wendy Wood 8, Michael Stanton 9, Harriet J Corbett 10, Dean Rex 11, Natalie Hutchings 12, Elizabeth Dixon 12, Simon Grist 13, William van’t Hoff 5, Esther Crawley 7, Jane Blazeby 14, Bridget Young 2

1 Faculty of Medicine, University of Southampton, Southampton, UK
2 Department of Health Services Research, Institute of Population Health Sciences, University of Liverpool, Liverpool, UK
3 University College London Great Ormond Street Institute of Child Health, Department of Population Health Sciences, University College London, London, UK
4 Primary Care and Population Sciences, Faculty of Medicine, University of Southampton, Southampton, UK
5 Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
6 Southampton Health Technology Assessment Centre, Faculty of Medicine, University of Southampton, Southampton, UK
7 Centre for Academic Child Health, Bristol Medical School, University of Bristol, Bristol, UK
8 National Institute for Health Research (NIHR), Research Design Service South Central, University of Southampton, Southampton, UK
9 Department of Paediatric Surgery and Urology, Southampton Children’s Hospital, University Hospital Southampton NHS Foundation Trust, Southampton, UK
10 Department of Paediatric Surgery, Alder Hey Children’s NHS Foundation Trust, Liverpool, UK
11 Department of Paediatric Surgery, St George’s University Hospitals NHS Foundation Trust, London, UK
12 Southampton Clinical Trials Unit, University of Southampton, Southampton, UK
13 Patient and public involvement representative, ,
14 Centre for Surgical Research, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
* Corresponding author Email: n.j.hall@soton.ac.uk

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