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There is limited evidence and much uncertainty in relation to the clinical and cost-effectiveness of enzyme-linked immunosorbent assay-based therapeutic drug monitoring in rheumatoid arthritis.

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Irina A Tikhonova 1,2,*, Huiqin Yang 1, Segun Bello 1, Andrew Salmon 3, Sophie Robinson 1, Mohsen Rezaei Hemami 1, Sophie Dodman 1, Andriy Kharechko 1, Richard C Haigh 4, Meghna Jani 5, Timothy J McDonald 4,6, Martin Hoyle 1

1 Peninsula Technology Assessment Group (PenTAG), University of Exeter Medical School, Exeter, UK
2 Southampton Health Technology Assessments Centre, University of Southampton, Southampton, UK
3 Peninsula Collaboration for Health Operational Research and Development, University of Exeter Medical School, Exeter, UK
4 Royal Devon & Exeter NHS Foundation Trust, Exeter, UK
5 Division of Musculoskeletal & Dermatological Sciences, University of Manchester, Manchester, UK
6 University of Exeter Medical School, Exeter, UK
* Corresponding author Email:

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