Validation and development of models using clinical, biochemical and ultrasound markers for predicting pre-eclampsia: an individual participant data meta-analysis

Allotey, John; Snell, Kym IE; Smuk, Melanie; Hooper, Richard; Chan, Claire L; Ahmed, Asif; Chappell, Lucy C; von Dadelszen, Peter; Dodds, Julie; Green, Marcus; Kenny, Louise; Khalil, Asma; Khan, Khalid S; Mol, Ben W; Myers, Jenny; Poston, Lucilla; Thilaganathan, Basky; Staff, Anne C; Smith, Gordon CS; Ganzevoort, Wessel; Laivuori, Hannele; Odibo, Anthony O; Ramírez, Javier A; Kingdom, John; Daskalakis, George; Farrar, Diane; Baschat, Ahmet A; Seed, Paul T; Prefumo, Federico; da Silva Costa, Fabricio; Groen, Henk; Audibert, Francois; Massé, Jacques; Skråstad, Ragnhild B; Salvesen, Kjell Å; Haavaldsen, Camilla; Nagata, Chie; Rumbold, Alice R; Heinonen, Seppo; Askie, Lisa M; Smits, Luc JM; Vinter, Christina A; Magnus, Per M; Eero, Kajantie; Villa, Pia M; Jenum, Anne K; Andersen, Louise B; Norman, Jane E; Ohkuchi, Akihide; Eskild, Anne; Bhattacharya, Sohinee; McAuliffe, Fionnuala M; Galindo, Alberto; Herraiz, Ignacio; Carbillon, Lionel; Klipstein-Grobusch, Kerstin; Yeo, SeonAe; Teede, Helena J; Browne, Joyce L; Moons, Karel GM; Riley, Richard D; Thangaratinam, Shakila

doi:10.3310/hta24720

An error occurred retrieving content to display, please try again.

Page not found (404)

Sorry - the page you requested could not be found.

Please choose a page from the navigation or try a website search above to find the information you need.

Toolkit

View Project

For existing models that could be validated, predictive performance was generally poor and although the IPPIC models showed promising predictive performance on average, heterogeneity was likely in calibration performance.

John Allotey , Kym IE Snell , Melanie Smuk , Richard Hooper , Claire L Chan , Asif Ahmed , Lucy C Chappell , Peter von Dadelszen , Julie Dodds , Marcus Green , Louise Kenny , Asma Khalil , Khalid S Khan , Ben W Mol , Jenny Myers , Lucilla Poston , Basky Thilaganathan , Anne C Staff , Gordon CS Smith , Wessel Ganzevoort , Hannele Laivuori , Anthony O Odibo , Javier A Ramírez , John Kingdom , George Daskalakis , Diane Farrar , Ahmet A Baschat , Paul T Seed , Federico Prefumo , Fabricio da Silva Costa , Henk Groen , Francois Audibert , Jacques Massé , Ragnhild B Skråstad , Kjell Å Salvesen , Camilla Haavaldsen , Chie Nagata , Alice R Rumbold , Seppo Heinonen , Lisa M Askie , Luc JM Smits , Christina A Vinter , Per M Magnus , Kajantie Eero , Pia M Villa , Anne K Jenum , Louise B Andersen , Jane E Norman , Akihide Ohkuchi , Anne Eskild , Sohinee Bhattacharya , Fionnuala M McAuliffe , Alberto Galindo , Ignacio Herraiz , Lionel Carbillon , Kerstin Klipstein-Grobusch , SeonAe Yeo , Helena J Teede , Joyce L Browne , Karel GM Moons , Richard D Riley & Shakila Thangaratinam .

Detailed Author information
Detailed Author information

John Allotey ^1,^2,^†, Kym IE Snell ^3,^*,^†, Melanie Smuk ², Richard Hooper ², Claire L Chan ², Asif Ahmed ⁴, Lucy C Chappell ⁵, Peter von Dadelszen ⁵, Julie Dodds ^1,², Marcus Green ⁶, Louise Kenny ⁷, Asma Khalil ⁸, Khalid S Khan ^1,², Ben W Mol ⁹, Jenny Myers ¹⁰, Lucilla Poston ⁵, Basky Thilaganathan ⁸, Anne C Staff ^11,¹², Gordon CS Smith ¹³, Wessel Ganzevoort ¹⁴, Hannele Laivuori ^15,^16,^17,¹⁸, Anthony O Odibo ¹⁹, Javier A Ramírez ²⁰, John Kingdom ²¹, George Daskalakis ²², Diane Farrar ²³, Ahmet A Baschat ²⁴, Paul T Seed ⁵, Federico Prefumo ²⁵, Fabricio da Silva Costa ²⁶, Henk Groen ²⁷, Francois Audibert ²⁸, Jacques Massé ²⁹, Ragnhild B Skråstad ^30,³¹, Kjell Å Salvesen ^32,³³, Camilla Haavaldsen ³⁴, Chie Nagata ³⁵, Alice R Rumbold ³⁶, Seppo Heinonen ³⁷, Lisa M Askie ³⁸, Luc JM Smits ³⁹, Christina A Vinter ⁴⁰, Per M Magnus ⁴¹, Kajantie Eero ^42,⁴³, Pia M Villa ³⁷, Anne K Jenum ⁴⁴, Louise B Andersen ^45,⁴⁶, Jane E Norman ⁴⁷, Akihide Ohkuchi ⁴⁸, Anne Eskild ^34,⁴⁹, Sohinee Bhattacharya ⁵⁰, Fionnuala M McAuliffe ⁵¹, Alberto Galindo ^52,⁵³, Ignacio Herraiz ⁵⁴, Lionel Carbillon ⁵⁵, Kerstin Klipstein-Grobusch ⁵⁶, SeonAe Yeo ⁵⁷, Helena J Teede ⁵⁸, Joyce L Browne ⁵⁶, Karel GM Moons ^56,⁵⁹, Richard D Riley ³, Shakila Thangaratinam ^1,²

^* Corresponding author Email: k.snell@keele.ac.uk

Funding: {{metadata.Funding}}

{{metadata.Journal}} Volume: {{metadata.Volume}}, Issue: {{metadata.Issue}}, Published in {{metadata.PublicationDate | date:'MMMM yyyy'}}

https://doi.org/{{metadata.DOI}}

Citation: {{author}}{{ (($index < metadata.AuthorsArray.length-1) && ($index <=6)) ? ', ' : '' }}{{(metadata.AuthorsArray.length <= 6) ? '.' : '' }} {{(metadata.AuthorsArray.length > 6) ? 'et al.' : ''}} . {{metadata.JournalShortName}} {{metadata.PublicationDate | date:'yyyy'}};{{metadata.Volume}}({{metadata.Issue}})

Report Content

Full Report
Abstract
Plain English Summary
Plain Language Summary
Scientific Summary

The full text of this issue is available as a PDF document from the Toolkit section on this page.

Responses to this report

No responses have been published.

If you would like to submit a response to this publication, please do so using the form below:

Comments submitted to the NIHR Journals Library are electronic letters to the editor. They enable our readers to debate issues raised in research reports published in the Journals Library. We aim to post within 14 working days all responses that contribute substantially to the topic investigated, as determined by the Editors. Non-relevant comments will be deleted.

Your name and affiliations will be published with your comment.

Once published, you will not have the right to remove or edit your response. The Editors may add, remove, or edit comments at their absolute discretion.

Enter response message*

Name (title, first name, last name)*

Occupation / Job title*

Affiliation / Employer*

Email*

Other authors
For example, if you are responding as a team or group. Please ensure you include full names and separate these using commas

Statement of competing interests
We believe that readers should be aware of any competing interests (conflicts of interest).
The International Committee of Medical Journal Editors (ICMJE) define competing interests as including: financial relationships with industry (for example through employment, consultancies, stock, ownership, honoraria, and expert testimony), either directly or through immediate family; personal relationships; academic competition; and intellectual passion.

If yes, please provide details below

Enter response title*

Enter CAPTCHA What is six multiplied by three?*

By submitting your response, you are stating that you agree to the terms & conditions