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Progesterone in the first trimester did not result in a higher rate of live births, but a subgroup analysis suggested some effect in women with more previous miscarriages.

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Arri Coomarasamy 1,*, Hoda M Harb 1, Adam J Devall 1, Versha Cheed 2, Tracy E Roberts 2, Ilias Goranitis 3, Chidubem B Ogwulu 2, Helen M Williams 1, Ioannis D Gallos 1, Abey Eapen 4, Jane P Daniels 5, Amna Ahmed 6, Ruth Bender-Atik 7, Kalsang Bhatia 8, Cecilia Bottomley 9, Jane Brewin 10, Meenakshi Choudhary 11, Fiona Crosfill 12, Shilpa Deb 13, W Colin Duncan 14, Andrew Ewer 1, Kim Hinshaw 6, Thomas Holland 15, Feras Izzat 16, Jemma Johns 17, Mary-Ann Lumsden 18, Padma Manda 19, Jane E Norman 14, Natalie Nunes 20, Caroline E Overton 21, Kathiuska Kriedt 9, Siobhan Quenby 22, Sandhya Rao 23, Jackie Ross 17, Anupama Shahid 24, Martyn Underwood 25, Nirmala Vaithilingham 26, Linda Watkins 27, Catherine Wykes 28, Andrew W Horne 14, Davor Jurkovic 9, Lee J Middleton 2

1 Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
2 Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
3 Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia
4 Carver College of Medicine, University of Iowa Health Care, Iowa City, IA, USA
5 Faculty of Medicine and Health Sciences, Queen’s Medical Centre, University of Nottingham, Nottingham, UK
6 Sunderland Royal Hospital, City Hospitals Sunderland NHS Foundation Trust, Sunderland, UK
7 Miscarriage Association, Wakefield, UK
8 Burnley General Hospital, East Lancashire Hospitals NHS Trust, Burnley, UK
9 University College Hospital, University College London Hospitals NHS Foundation Trust, London, UK
10 Tommy’s, London, UK
11 Royal Victoria Infirmary, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
12 Royal Preston Hospital, Lancashire Teaching Hospitals NHS Trust, Preston, UK
13 Queen’s Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK
14 Medical Research Council Centre for Reproductive Health, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK
15 St Thomas’ Hospital, Guy’s and St Thomas’ NHS Foundation Trust, London, UK
16 University Hospital Coventry, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK
17 King’s College Hospital, King’s College Hospital NHS Foundation Trust, London, UK
18 Reproductive & Maternal Medicine, School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow, UK
19 The James Cook University Hospital, South Tees Hospitals NHS Foundation Trust, Middlesbrough, UK
20 West Middlesex University Hospital, Chelsea and Westminster Hospital NHS Foundation Trust, Isleworth, UK
21 St Michael’s Hospital, University Hospitals Bristol NHS Foundation Trust, Bristol, UK
22 Biomedical Research Unit in Reproductive Health, Warwick Medical School, University of Warwick, Coventry, UK
23 Whiston Hospital, St Helen’s and Knowsley Teaching Hospitals NHS Trust, Prescot, UK
24 Whipps Cross Hospital, Barts Health NHS Trust, London, UK
25 Princess Royal Hospital, Shrewsbury and Telford Hospital NHS Trust, Telford, UK
26 Queen Alexandra Hospital, Portsmouth Hospitals NHS Trust, Portsmouth, UK
27 Liverpool Women’s Hospital, Liverpool Women’s NHS Foundation Trust, Liverpool, UK
28 East Surrey Hospital, Surrey and Sussex Healthcare NHS Trust, Redhill, UK
* Corresponding author Email:

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