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This trial found that 3 months of oxaliplatin-containing adjuvant chemotherapy was non-inferior to 6-months in terms of disease-free survival, with a better safety profile and lower costs.

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Timothy Iveson 1,*, Kathleen A Boyd 2, Rachel S Kerr 3, Jose Robles-Zurita 2, Mark P Saunders 4, Andrew H Briggs 2, Jim Cassidy 5, Niels Henrik Hollander 6, Josep Tabernero 7, Andrew Haydon 8, Bengt Glimelius 9, Andrea Harkin 5, Karen Allan 5, John McQueen 5, Sarah Pearson 10, Ashita Waterston 11, Louise Medley 12, Charles Wilson 13, Richard Ellis 14, Sharadah Essapen 15, Amandeep S Dhadda 16, Mark Harrison 17, Stephen Falk 18, Sherif Raouf 19, Charlotte Rees 1, Rene K Olesen 20, David Propper 21, John Bridgewater 22, Ashraf Azzabi 23, David Farrugia 24, Andrew Webb 25, David Cunningham 26, Tamas Hickish 27, Andrew Weaver 28, Simon Gollins 29, Harpreet Wasan 30, James Paul 4

1 Southampton University Hospital NHS Foundation Trust, Southampton, UK
2 Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK
3 Department of Oncology, University of Oxford, Oxford, UK
4 The Christie Hospital NHS Foundation Trust, Manchester, UK
5 Cancer Research UK Clinical Trials Unit, Institute of Cancer Sciences, University of Glasgow, Glasgow, UK
6 Department of Oncology and Palliative Care, Zealand University Hospital, Naestved, Denmark
7 Vall d’Hebron University Hospital and Institute of Oncology, Universitat Autònoma de Barcelona, Barcelona, Spain
8 Australasian Gastro-Intestinal Trials Group, Camperdown, NSW, Australia
9 University of Uppsala, Uppsala, Sweden
10 Oncology Clinical Trials Office, Department of Oncology, University of Oxford, Oxford, UK
11 Beatson West of Scotland Cancer Centre, Glasgow, UK
12 Royal United Hospital, Bath, UK
13 Addenbrooke’s Hospital, Cambridge, UK
14 Royal Cornwall Hospitals NHS Trust, Cornwall, UK
15 St Luke’s Cancer Centre, Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK
16 Castle Hill Hospital, Hull, UK
17 Mount Vernon Cancer Centre, Northwood, UK
18 Bristol Cancer Institute, Bristol, UK
19 Barking Havering and Redbridge University Hospital NHS Trust, Barking, UK
20 Department of Oncology, Aarhus University Hospital, Aarhus, Denmark
21 Barts Cancer Institute, Queen Mary University of London, London, UK
22 Department of Oncology, University College London, London, UK
23 Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
24 Gloucestershire Oncology Centre, Cheltenham General Hospital, UK
25 Brighton and Sussex University Hospital Trust, Brighton, UK
26 Royal Marsden NHS Foundation Trust, London, UK
27 Poole Hospital NHS Foundation Trust, Poole, UK
28 Department of Oncology, Oxford University Hospitals Foundation Trust, Oxford, UK
29 North Wales Cancer Treatment Centre, Rhyl, UK
30 Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, UK
* Corresponding author Email: tim.iveson@uhs.nhs.uk

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