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During the 12 weeks from new diagnosis, the addition of prophylactic levofloxacin to active myeloma treatment significantly reduced febrile episodes and deaths without increasing healthcare associated infections or carriage.

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Mark T Drayson 1,*, Stella Bowcock 2, Tim Planche 3, Gulnaz Iqbal 4, Guy Pratt 5, Kwee Yong 6, Jill Wood 4, Kerry Raynes 4, Helen Higgins 4, Bryony Dawkins 7, David Meads 7, Claire T Hulme 7, Anna C Whittaker 8, Peter Hawkey 9, Eric Low 10, Janet A Dunn 4

1 Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK
2 King’s College Hospital NHS Foundation Trust, London, UK
3 Institute of Infection and Immunity, St George’s Hospital, University of London, London, UK
4 Warwick Clinical Trials Unit, University of Warwick, Coventry, UK
5 University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
6 Department of Haematology, University College London Cancer Institute, London, UK
7 Academic Unit of Health Economics, University of Leeds, Leeds, UK
8 School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK
9 Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK
10 Patient Advocacy, Myeloma UK, Edinburgh, UK
* Corresponding author Email: M.T.Drayson@bham.ac.uk

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